Genes Encoding Carbocycle-Forming Enzymes Involved in Aminoglycoside Biosynthesis in Deep-Sea Environmental DNA
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概要
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We obtained 19 individual DNA fragments encoding 2-deoxy-scyllo-inosose synthase involved in the biosynthesis of aminoglycoside antibiotics from deep-sea sediments of the Pacific Ocean. Compared with genes from land-based environmental DNA, they showed low diversity. Combined with our previous study concerning the discovery of other aminoglycoside-biosynthetic genes from the same deep-sea samples, we suggest the importance of exploration of multiple biosynthetic genes to determine the diversity of aminoglycoside producers. We found that the deep sea is a useful source for screening of these genes.
- 2010-05-23
著者
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Kato Chiaki
Extremobiosphere Res. Center Japan Agency For Marine-earth Sci. And Technol.
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Tamegai Hideyuki
Department Of Chemistry College Of Humanities And Sciences Nihon University
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KANDA Yumi
Department of Chemistry, College of Humanities and Sciences, Nihon University
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Kanda Yumi
Department Of Chemistry College Of Humanities And Sciences Nihon University
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