NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Modulates the Effects of Coffee Consumption on the Risk of Hypertension in Middle-Aged Japanese Men
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概要
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Background: Habitual coffee consumption has been reported to lower blood pressure in the Japanese population. The NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity and modifies the effects of alcohol consumption on blood pressure in the Japanese population. The objective of this study was to determine whether this polymorphism also modifies the effects of coffee consumption on blood pressure or the risk of hypertension in middle-aged Japanese men.Methods: A total of 398 men (mean age ± standard deviation, 53.8 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. Hypertension was defined as a systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or antihypertensive drug treatment. Polymerase chain reaction-restriction fragment length polymorphism using the restriction enzyme AluI was performed to determine ND2-237 Leu/Met genotype.Results: In subjects with ND2-237Leu, coffee consumption was significantly and negatively associated with diastolic blood pressure (P = 0.007). The odds ratio (OR) for hypertension was significantly lower in subjects with ND2-237Leu who consumed 2 or 3 cups of coffee per day than in those who consumed less than 1 cup of coffee per day (OR, 0.517; 95% confidence interval [CI], 0.276 to 0.968; P = 0.039). After adjustment, the OR remained significant (OR = 0.399; 95% CI, 0.184 to 0.869; P = 0.020). Moreover, after adjustment, the OR was significantly lower in subjects with ND2-237Leu who consumed more than 4 cups of coffee per day than in those who consumed less than 1 cup of coffee per day (OR, 0.246; 95% CI, 0.062 to 0.975; P = 0.046). However, the association between ND2-237Met genotype and hypertension did not depend on coffee consumption.Conclusions: The present results suggest that the ND2-237 Leu/Met polymorphism modulates the effects of coffee consumption on hypertension risk in middle-aged Japanese men.
- 2009-09-01
著者
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Yoshida Mika
Faculty Of Agriculture Hokkaido University
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Yoshida M
Department Of Public Health Kyorin University School Of Medicine
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Takagi Y
Division Of Cardiovascular Surgery Kamo Hospital
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Ohida T
鳥取大学 医学部環境予防医学分野
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Ohida Takashi
Department Of Public Health Administration National Institute Of Public Health
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Yoshida Masao
Department Of Transportation Engineering Faculty Of Science And Technology Meijo University
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TAKASHIMA Yutaka
Department of Preventive Medicine and Public Health, School of Medicine, Kyorin University
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KARITA KANAE
Department of Hygiene and Public Health, School of Medicine, Teikyo University
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KOKAZE Akatsuki
Department of Public health, Kyorin university School of medicine
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ISHIKAWA Mamoru
Department of Public Health, Kyorin University School of Medicine
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MATSUNAGA Naomi
Department of Public Health, Kyorin University School of Medicine
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OHTSU Tadahiro
Department of Public Health, Showa University School of Medicine
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SHIRASAWA Takako
Department of Public Health, Showa University School of Medicine
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SEKII Hideaki
Department of Public Health, Showa University School of Medicine
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ITO Taku
Department of Public Health, Showa University School of Medicine
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KAWAMOTO Teruyoshi
Department of Public Health, Showa University School of Medicine
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Yoshida Masao
Department Of Public Health Kyorin University School Of Medicine
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Yoshida M
Ibaraki Univ. Inashiki‐gun Jpn
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Ito Taku
Department Of Public Health Showa University School Of Medicine
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Masuda Yumi
Department Of Public Health Kyorin University School Of Medicine
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Karita Kanae
Department Of Hygiene And Public Health Kyorin University School Of Medicine
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Sekii Hideaki
Department Of Public Health Showa University School Of Medicine
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Ito Taku
Department Of Cellular And Molecular Biology Institute Of Medical Science University Of Tokyo
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Takashima Yutaka
Department Of Public Health Kyorin University School Of Medicine
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Ishikawa Mamoru
Department Of Internal Medicine Kitasato University School Of Medicine
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Karita Kanae
Department Of Public Health Kyorin University School Of Medicine
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Ohtsu Tadahiro
Department Of Public Health Nihon University School Of Medicine
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Ohida Takashi
Department Of Public Health Showa University School Of Medicine
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Ito Taku
Department Of Cancer Biology Division Of Cellular And Molecular Biology University Of Tokyo
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Shirasawa Takako
Department Of Public Health Showa University School Of Medicine
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Yoshida Masao
Department Of Chemistry Faculty Of Science Science University Of Tokyo
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Kokaze Akatsuki
Department Of Public Health Showa University School Of Medicine
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Matsunaga Naomi
Department Of Public Health Kyorin University School Of Medicine
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Ishikawa Mamoru
Department Of Public Health Kyorin University School Of Medicine
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Kawamoto Teruyoshi
Department Of Public Health Showa University School Of Medicine
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YOSHIDA Masao
Department of Public Health, Kyorin University School of Medicine
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Yoshida Masao
Department of Bioresource Science, Ibaraki University College of Agriculture
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KOKAZE Akatsuki
Department of Parasitology, Institute of Medical Science, The University of Tokyo
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TAKASHIMA YUTAKA
Department of Microbiology Public Health, School of Medicine, Keio University.
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