Relations of Blood Pressure to Angiotensinogen Gene T174M Polymorphism and Alcohol Intake

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概要

• 論文の詳細を見る

• To clarify the interactive effects of alcohol intake and angiotensinogen gene codon 174 (T174M) polymorphisms on blood pressure in Japanese male workers. On the basis of data from health examinations, nutrition survey and T174M genotype analysis conducted for 185 Japanese male workers at 2000, the prevalence of high-normal blood pressure (HNBP) and hypertension were compared between the four subgroups crossed by two T174M genotype categories ('TT' type, and 'TM or MM' type) and two alcohol intake categories (less than 13.7g per day, and 13.7g or more per day). Furthermore, for 95 subjects who had been normotensive at 1998 among them, risk of development into HNBP or hypertension at 2000 were compared across the four subgroups. The findings showed that the HNBP prevalence adjusted for age, body mass index, smoking habits and sodium intake in 2000 was significantly (p=0.03) greater in 'TM or MM' type (57.9%) than in 'TT' type (24.9%) in subjects with 13.7g or more of daily alcohol intake, whereas no difference in this parameter was found between the two genotypes in those with less than 13.7g of daily alcohol intake (18.2% and 18.3%, respectively). The risk for development into HNBP at 2000 was also greatest in 'TM or MM' type with 13.7g or more of daily alcohol intake among the four subgroups, although there were not significant differences between the four subgroups. The prevalence of hypertension or development risk for hypertension did not significantly differ between the four subgroups. Therefore, it can be seen that alcohol drinking might be specifically associated with the HNBP in M allele carriers of angiotensinogen gene T174M polymorphism.

• 日本生理人類学会の論文

著者

• Shibui Kayo

  Department Of Psychophysiology National Institute Of Mental Health Ncnp

• Yoshida Mika

  Faculty Of Agriculture Hokkaido University

• Yoshida M

  Department Of Public Health Kyorin University School Of Medicine

• Takagi Y

  Division Of Cardiovascular Surgery Kamo Hospital

• Yoshida Masao

  Department Of Transportation Engineering Faculty Of Science And Technology Meijo University

• Shibui Kayo

  恩方病院

• TAKASHIMA Yutaka

  Department of Preventive Medicine and Public Health, School of Medicine, Kyorin University

• SEKINE Yasuko

  Department of Breast Surgery, Cancer Institute Hospital

• SEKIGUCHI Kanako

  Ongata Hospital

• KOKAZE Akatsuki

  Department of Public health, Kyorin university School of medicine

• MATSUNAGA Naomi

  Department of Public Health, Kyorin University School of Medicine

• SEKIGUCHI Kanako

  Department of Public Health, Kyorin University, School of Medicine

• Sumiya Yu

  Department of Public Health, Kyorin University School of Medicine

• Sumiya Yu

  Department Of Public Health Kyorin University School Of Medicine

• Yoshida Masao

  Department Of Public Health Kyorin University School Of Medicine

• Yoshida M

  Ibaraki Univ. Inashiki‐gun Jpn

• Masuda Yumi

  Department Of Public Health Kyorin University School Of Medicine

• Sekine Yasuko

  Department Of Public Health Kyorin University School Of Medicine

• Sekine Yasuko

  Department Of Breast Surgery Cancer Institute Hospital

• Takashima Yutaka

  Department Of Public Health Kyorin University School Of Medicine

• Sekiguchi Kanako

  Department Of Public Health Kyorin University School Of Medicine

• Shibui Kayo

  Department Of Psychophysiology National Institute Of Mental Health National Center Of Neurology And

• Yoshida Masao

  Department Of Chemistry Faculty Of Science Science University Of Tokyo

• Kokaze Akatsuki

  Department Of Public Health Showa University School Of Medicine

• Matsunaga Naomi

  Department Of Public Health Kyorin University School Of Medicine

• Sekine Yasuko

  Deparrment of Public Health, Kyorin University School of Medicine

• YOSHIDA Masao

  Department of Public Health, Kyorin University School of Medicine

• Yoshida Masao

  Department of Bioresource Science, Ibaraki University College of Agriculture

• KOKAZE Akatsuki

  Department of Parasitology, Institute of Medical Science, The University of Tokyo

• TAKASHIMA YUTAKA

  Department of Microbiology Public Health, School of Medicine, Keio University.

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