Ablation of Nrf2 Function Does Not Increase the Erythroid or Megakaryocytic Cell Lineage Dysfunction Caused by p45 NF-E2 Gene Disruption.
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概要
- 論文の詳細を見る
Maf recognition elements (MAREs or NF-E2 binding sites) have been shown to be vital for erythroid- and megakaryocyte-specific gene expression. Transcription factor NF-E2 is composed of p45, a large subunit belonging to the CNC family proteins, and a small Maf subunit, and is thought to activate transcription through its binding to MAREs in both the erythroid and megakaryocytic cell lineages. While p45 gene knockout mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes, and the mutant mice die of massive bleeding within a week after birth, anemia is not apparent in these animals. Disruption of the nrf2 gene, encoding another CNC family protein, results in no hematological abnormalities. We have therefore tested the hypothesis that Nrf2 might compensate for the p45 deficiency in erythroid lineage cells of p45-knockout mice, thereby masking the anticipated anemia. However, we failed to detect any greater failure in either erythroid or megakaryocytic cell development in Nrf2 plus p45 compound mutant mice as compared to with either individual homozygous mutation. These data suggest that p45 and Nrf2 may both be dispensable for hematopoietic cell development, and that other factors regulate erythroid- and megakaryocyte-specific gene expression through their required MAREs.
- 社団法人 日本生化学会の論文
著者
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Kuroha Takashi
Institute Of Basic Medical Sceinces And Center For Tara
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Nagasawa Toshiro
Division Of Clinical And Experimental Hematology Major Of Advanced Biochemical Applications Graduate
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KOMENO Takuya
Division of Hematology, Institute of Clinical medicine, University of Tsukuba
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ITOH Ken
Institute of Basic Medical Sceinces and Center for TARA
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Komeno Takuya
Division Of Hematology Institute Of Clinical Medicine University Of Tsukuba
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Yamamoto Masayuki
Institute Of Basic Medical Sciences And Center For Tsukuba Advanced Research Alliance University Of
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Takahashi Satoru
Institute Of Basic Medical Sceinces And Center For Tara
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