Conserved Structure, Regulatory Elements, and Transcriptional Regulation from the GATA-1 Gene Testis Promoter.
スポンサーリンク
概要
- 論文の詳細を見る
Transcription factor GATA-1 was first identified in erythroid cells, but was later shown to also be expressed in Sertoli cells of the mouse testis. GATA-1 transcription in testis initiates from a different first exon (exon IT) than the erythroid mRNA (transcribed from exon IE). To begin to address the question of how expression of GATA-1 might be differentially regulated in Sertoli and erythroid cells, we have cloned and determined the structure of the IT promoters of both the rat and mouse GATA-1 genes. The transcription regulatory mechanism(s) controlling the synthesis of exon IT-derived mRNA was inves-tigated by transfection of wild-type and mutant reporter genes, with and without co-trans-fected GATA factor expression plasmids, into either fibroblasts or Sertoli cell lines. Two GATA binding sites in the IT promoter were found to be required for GATA factor-mediated activation in fibroblasts: GATA-IT-directed reporter gene expression was activated only after co-transfection with GATA-1, implying that transcriptional activation of GATA-1 in the testis might be at least partially mediated through these GATA regulatory elements. We also found that the endogenous GATA-1 gene was silent in primary culture and two different Sertoli cell lines, and that the repression of co-transfected GATA-IT reporter genes could not be relieved by forced expression of GATA-1 in Sertoli cells. Thus the GATA-IT promoter may be under the control of a regulatory network in Sertoli cells which involves both positive and negative regulation of transcription, and conserved GATA motifs found in the IT promoter may be required for transducing these effects.
- 社団法人 日本生化学会の論文
著者
-
YOMOGIDA Kentaro
Institute of Basic Medical Sciences and Center for TARA, University of Tsukuba
-
Onodera Ko
Department Of Biochemistry Tohoku University School Of Medicine
-
Engel James
Department Of Biochemistry Molecular Biology And Cell Biollogy Northwestern University
-
Gu Lin
Department Of Biochemistry Molecular Biology And Cell Biology Northwestern University
-
Suwabe Naruyoshi
Department Of Biochemistry Tohoku University School Of Medicine
-
Muraosa Yasushi
Department Of Biochemistry Tohoku University School Of Medicine
-
Ito Etsuro
Department Of Pediatrics Hirosaki University Graduate School Of Medicine
-
Hayashi Norio
Department Of Biochemistry School Of Medicine Tohoku University
-
Takahashi Satoru
Institute Of Basic Medical Sceinces And Center For Tara
-
Yamamoto Masayuki
Department of Anatomy, Hiroshima University school of Medicine
-
Rassoulzadegan Minoo
Unité 273 de l'Institut National de la Santé et de la Recherche Médicale Université de Nice
関連論文
- Dense deposit disease presenting as endocapillary proliferative nephritis
- Retinoic acid-inducible gene-I( RIG-I) and diseases
- Renal Biopsy Findings in Children Receiving Long-Term Treatment with Cyclosporine A Given as a Single Daily Dose
- Mizoribine Pulse Therapy for a Pediatric Patient with Steroid-Resistant Nephrotic Syndrome
- Effective Therapy of a Child Case of Refractory Nephrotic Syndrome with Tacrolimus
- Combined therapy of enalapril and losartan attenuates histologic progression in immunoglobulin A nephropathy
- Therapy-related membranous nephropathy in juvenile idiopathic arthritis with Turner syndrome
- Mizoribine oral pulse therapy for a patient with severe lupus nephritis
- End-Stage Kidney at the Onset of Nephrotic Syndrome in a 4-Year-Old Girl
- Acute renal failure due to hypertension : Malignant hypertension in an adolescent
- Disseminated candidiasis following prednisolone therapy in systemic lupus erythematosus
- Tubulointerstitial Nephritis and Uveitis Syndrome in Two Siblings
- Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients
- Cloning and Characterization of the Novel Chimeric Gene p53/FXR2 in the Acute Megakaryoblastic Leukemia Cell Line CMK11-5
- Expression of Transcription Factors during Megakaryocytic Differentiation of CD34^+ Cells from Human Cord Blood Induced by Thrombopoietin
- Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemia with MLL gene rearrangement
- Successful Outcome of Mismatched Hematopoietic Stem Cell Transplantation from a Related Donor in an Infant with Acute Lymphoblastic Leukemia and 9 ; 11 Translocation : Case Report and Review of the Literature
- Hemolytic crisis with fulminant hepatic failure in Wilson disease without consanguinity
- Low serum lipids suggest severe bone marrow failure in children with aplastic anemia
- Sporadic case of hemoglobin Bushwick detected by chance in aplastic crisis
- Fatal Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis With Clonal Karyotype Abnormality
- Risk of Etoposide-Related Acute Myeloid Leukemia in the Treatment of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis
- Hepatocyte growth factor in transient myeloproliferative disorder of Down syndrome
- The Promoter of Mouse Transcription Repressor bach1 Is Regulated by Sp1 and Trans-Activated by Bach^1
- Distinct Clones Are Associated with the Development of Transient Myeloproliferative Disorder and Acute Megakaryocytic Leukemia in a Patient with Down Syndrome
- Conserved Structure, Regulatory Elements, and Transcriptional Regulation from the GATA-1 Gene Testis Promoter^1
- Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C
- A novel therapeutic strategy with anti-CD9 antibody in gastric cancers
- Lamivudine-to-entecavir switching treatment in type B chronic hepatitis patients without evidence of lamivudine resistance
- Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization
- Factors contributing to antiviral effect of adefovir dipivoxil therapy added to ongoing lamivudine treatment in patients with lamivudine-resistant chronic hepatitis B
- Effect of interferon α-2b plus ribavirin therapy on incidence of hepatocellular carcinoma in patients with chronic hepatitis
- Serum levels of soluble major histocompatibility complex (MHC) class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma
- Early emergence of entecavir-resistant hepatitis B virus in a patient with hepatitis B virus/human immunodeficiency virus coinfection
- Early decline of hemoglobin can predict progression of hemolytic anemia during pegylated interferon and ribavirin combination therapy in patients with chronic hepatitis C
- Early decline of hemoglobin correlates with progression of ribavirin-induced hemolytic anemia during interferon plus ribavirin combination therapy in patients with chronic hepatitis C
- Reduced expression and functional impairment of Toll-like receptor 2 on dendritic cells in chronic hepatitis C virus infection
- Should aged patients with chronic hepatitis C be treated with interferon and ribavirin combination therapy?
- The significance of interferon and ribavirin combination therapy followed by interferon monotherapy for patients with chronic hepatitis C in Japan
- Juvenile hepatocellular carcinoma with congestive liver cirrhosis
- Interferon therapy for aged patients with chronic hepatitis C : improved survival in patients exhibiting a biochemical response
- Expression of Rab5a in hepatocellular carcinoma : Possible involvement in epidermal growth factor signaling
- Changes in gene expression profile by HCV core protein in cultured liver cells : analysis by DNA array assay
- Juvenile myelomonocytic leukemia presenting multiple painful erythematous lesions diagnosed as Sweet's syndrome
- IS HELICOBACTER PYLORI-INDUCED ENLARGED FOLD GASTRITIS A HIGH-RISK FACTOR FOR GASTRIC CARCINOMA?
- Roles of double-balloon endoscopy in the diagnosis and treatment of Crohn's disease : a multicenter experience
- Foods and beverages in relation to urothelial cancer : Case-control study in Japan
- Cultured bone marrow cell local implantation accelerates healing of ulcers in mice
- Serum HCV RNA levels during early phase of recombinant interferon alfa-2a (Roferon A) therapy for chronic hepatitis C and efficacy of short-term therapy with earlier loss of viremia
- Effectiveness of real-time virtual sonography-guided radiofrequency ablation treatment for patients with hepatocellular carcinomas
- Hypervascular hepatocellular carcinoma : Combined dynamic MDCT and SPIO-enhanced MRI versus combined CTHA and CTAP
- Restoration of gut motility in Kit-deficient mice by bone marrow transplantation
- Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice
- Genetic Analysis of Shwachman-Diamond Syndrome : Phenotypic Heterogeneity in Patients Carrying Identical SBDS Mutations
- New chemotherapy for patients with advanced hepatocellular carcinoma : Pilot study of β-interferon and doxorubicin one-shot intra-arterial chemotherapy
- Triple therapy of initial high-dose interferon with ribavirin and amantadine for patients with chronic hepatitis C
- A Family of Autosomal Dominant Hypocalcemia with an Activating Mutation of Calcium-Sensing Receptor Gene
- 5-Aminolevulinate Synthase Expression and Hemoglobin Synthesis in a Human Myelogenous Leukemia Cell Line^1
- The Crystal Structures of Mutated 3-Isopropylmalate Dehydrogenase from Thermus thermophilus HB8 and Their Relationship to the Thermostability of the Enzyme
- Semiempirical Calculations of Force Constants for Torsional and Stretching Vibrations in Excited States of Retinal and Its Related Compounds
- Improved Survival of Children with Advanced Neuroblastoma Treated by Intensified Therapy Including Myeloablative Chemotherapy with Stem Cell Transplantation : A Retrospective Analysis from the Tohoku Neuroblastoma Study Group
- Decrease in Thy-1 Expression on Peripheral CD34 Positive Cells Induced by G-CSF Mobilization
- Expression of GATA transcription factors in myelogenous and lymphoblastic leukemia cells
- Semiautomated volumetry of the cerebrum, cerebellum-brain stem, and temporal lobe on brain magnetic resonance images
- Recurrent erythroblastopenia associated with Varicella zoster virus infection in an infant
- Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice
- Disseminated Fusarium Infection Identified by the Immunohistochemical Staining in a Patient with a Refractory Leukemia
- Bach1 Deficiency Ameliorates Hepatic Injury in a Mouse Model
- Role of the Heme Regulatory Motif in the Heme-Mediated Inhibition of Mitochondrial Import of 5-Aminolevulinate Synthase
- Theory of Retinal and Its Related Compounds by the Extended INDO-CI Method Taking Account of the Change in Bond Lengths in Consistence with Electronic States
- Semiempirical Calculation of Force Constants of Stretching Vibrations in Excited States of Retinal and Its Related Compounds
- Changes in virus loads and precore mutations in chronic hepatitis B patients treated with 4 weeks of daily interferon alfa-2a therapy
- Antiviral therapy for chronic hepatitis C : past, present, and future
- Benefits of Once-Daily Administration of Cyclosporine A for Children with Steroid-Dependent, Relapsing Nephrotic Syndrome
- Measuring immunity in viral hepatitis
- The Effect of Cytokines on the Differentiation of an Eosinophilic Leukemia Cell Line (EoL - 1) is Associated with Down Regulation of c-myc Gene Expression
- Fas and Fas ligand in human hepatocellular carcinoma
- Management of hepatitis C ; Report of the Consensus Meeting at the 45th Annual Meeting of the Japan Society of Hepatology (2009)
- Development of a Method for Reconstructing Three-dimensional Data from Axial, Sagittal, and Coronal MR Images
- STAT3 signaling within hepatocytes is required for anemia of inflammation in vivo
- Adipocytokines and liver disease
- Molecular Pathogenesis of Viral Hepatitis
- Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia
- Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet
- Molecular pathogenesis in Diamond-Blackfan anemia
- Distinct susceptibility of dendritic cell subsets to hepatitis C virus infection : a plausible mechanism of dendritic cell dysfunction
- Innate immunity in hepatitis C virus infection : Interplay among dendritic cells, natural killer cells and natural killer T cells
- SHORT-TERM OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) FOR EARLY GASTRIC NEOPLASM : MULTICENTER SURVEY BY OSAKA UNIVERSITY ESD STUDY GROUP
- Endoscopic submucosal dissection as a treatment for gastric noninvasive neoplasia : a multicenter study by Osaka University ESD Study Group
- Structure and Regulation of the Chicken GATA-3 Gene
- Plasmablastic Extramedullary Plasmacytoma Associated with Epstein-Barr Virus Arising in an Immunocompetent Patient with Multiple Myeloma
- Successful Multidrug Treatment of a Pediatric Patient with Severe Churg-Strauss Syndrome Refractory to Prednisolone
- Dynamics of regulatory T cells and plasmacytoid dendritic cells as immune markers for virological response in pegylated interferon-α and ribavirin therapy for chronic hepatitis C patients
- Simultaneous R2* and Liver Fat-fraction Measurement Using Modulus and Real Multiple Gradient-echo with Low-field MRI
- Multiple organ failure(MOF) and nutritional support.
- Congenital segmental dilatation of the colon.
- Hypercalcemia Following Umbilical Cord Blood Transplantation to Correct Osteopetrosis Associated with the NEMO Mutation [Innovation in Transplant and Regenerative Medicine. The 13th Meeting of Hirosaki International Forum of Medical Science. Communication
- Organ Assimilation of Peptides
- Congenital segmental dilatation of the jejunum with malrotation.
- Conserved Structure, Regulatory Elements, and Transcriptional Regulation from the GATA-1 Gene Testis Promoter.