Fluid Dynamics and Electrical Detection of λDNA in Electrode-Embedded Nanochannels
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概要
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In the present study, we address theoretical approaches for the experimental results to investigate the flow dynamics of λDNA through a nanochannel in which two nanoelectrodes are integrated. In order to elucidate the relationship between the longitudinal ionic current and the electrophoresis of λDNA in the specific micro/nanofluidics, we develop a theoretical model for the macroscopic fluid dynamics in a Lagrangian framework. The measured current change associated with a single molecule translocation through the channel is explained by the principle of the Coulter counter that allowed to predict the conformation of λDNA. We also analyze the local velocity of λDNA passing through a nanoscaled confined channel. A result from the model is in considerable agreement with the experimental observations for the electrophoretic flow of λDNA. The basic knowledge obtained here may be useful in developing electrical methods for controlling the electrophoretic velocity of single-molecule DNA for realizing the nanopore sequencer.
- 一般社団法人 日本機械学会の論文
著者
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Kawai Tomoji
The Institute Of Science And Industrial Research (isir-sanken) Osaka University
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Doi Kentaro
Department Of Applied Physics And Chemistry The University Of Electro-communications
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Uehara Satoshi
Department Of Applied Chemistry And Biotechnology Faculty Of Engineering Chiba University
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Kawano Satoyuki
Department Of Mechanical Engineering And Bioengineering Graduate School Of Engineering Science Osaka
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TANIGUCHI Masateru
The Institute of Scientific and Industrial Research (ISIR), Osaka University
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TSUTSUI Makusu
The Institute of Scientific and Industrial Research (ISIR), Osaka University
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DOI Kentaro
Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University
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UEHARA Satoshi
Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University
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