Fabrication of Genetic Diagnostic Chip using DNA-arrayed TFT Photosensor
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概要
- 論文の詳細を見る
This work describes a disposable DNA-arrayed thin film transistor (TFT) photosensor integrating a miniaturized reaction unit and a photoelectronic effect-based internal detection sensor. Single stranded DNA was chemically conjugated and arrayed on the TFT photosensor, which was fabricated by the semiconductor integrated circuit (IC) technology, for the detection of specific target DNA by DNA-DNA hybridization. The photosensor surface can be modified by various silane coupling reagents for the optimization of oligonucleotide immobilization conditions and single nucleotide polymorphism (SNP) detection was successfully employed using the TFT photosensor. A microfluidic channels were constructed on the TFT photosensor to improve the hybridization efficiency. The developed TFT photosensor will further promote the development of disposable photodetecting devices applicable in genetic diagnosis.
- 公益社団法人 電気化学会の論文
著者
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Tanaka Tsuyoshi
Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University
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Mizutani Yasushi
Casio Computer Co. Ltd.
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Matsunaga Tadashi
Department Of Applid Chemistry For Resources Tokyo University Of Agriculture And Technology
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Sawaguchi Masahiro
Casio Computer Co. Ltd.
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Iwadate Akihito
Casio Computer Co. Ltd.
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Sasaki Kazuhiro
Casio Computer Co. Ltd.
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Tateishi Naofumi
Casio Computer Co. Ltd.
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HATAKEYAMA Keiichi
Department of Biotechnology, Tokyo University of Agriculture and Technology
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