Comprehensive evaluation of leukocyte lineage derived from human hematopoietic cells in humanized mice(CELL AND TISSUE ENGINEERING)
スポンサーリンク
概要
- 論文の詳細を見る
Recently, humanized animals whereby a part of the animal is biologically engineered using human genes or cells have been utilized to overcome interspecific differences. Herein, we analyzed the detail of the differentiation states of various human leukocyte subpopulations in humanized mouse and evaluated comprehensively the similarity of the leukocyte lineage between humanized mice and humans. Humanized mice were established by transplanting human CD34^+ cord blood cells into irradiated severely immunodeficient NOD/Shi-scid/IL2Rγ^<null> (NOG) mice, and the phenotypes of human cells contained in bone marrow, thymus, spleen and peripheral blood from the mice were analyzed at monthly intervals until 4 months after cell transplantation. The analysis revealed that transplanted human hematopoietic stem cells via the caudal vein homed and engrafted themselves successfully at the mouse bone marrow. Subsequently, the differentiated leukocytes migrated to the various tissues. Almost all of the leukocytes within the thymus were human cells. Furthermore, analysis of the differentiation states of human leukocytes in various tissues and organs indicated that it is highly likely that the human-like leukocyte lineage can be developed in mice.
- 公益社団法人日本生物工学会の論文
著者
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Yoshino Tomoko
Tokyo Univ. Agri. Tech.
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NAKASONO Satoshi
Environmental Science Research Laboratory
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Otsuka Kensuke
Radiation Safety Res. Center Nuclear Technol. Res. Lab. Central Res. Inst. Of Electric Power Ind.
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Matsunaga Tadashi
Department Of Applid Chemistry For Resources Tokyo University Of Agriculture And Technology
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Matsunaga Tadashi
Tokyo University Of Agriculture & Technology
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Mori Tetsushi
Tokyo Univ. Agri. Tech.
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Nakasono Satoshi
Central Research Institute of Electric Power Industry
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YOSHINO Tomoko
Department of Biotechnology, Tokyo University of Agriculture and Technology
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Takahashi Masayuki
Environmental Risk Assessment Sector, Environmental Science Research Laboratory, Central Research In
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Tsujimura Noriyuki
Department of Biotechnology, Tokyo University of Agriculture and Technology
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Mori Tetsushi
Department of Biotechnology, Tokyo University of Agriculture and Technology
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Yoshino Tomoko
Department Of Biotechnology Tokyo University Of Agriculture And Technology
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Mori Tetsushi
Department Of Biotechnology Tokyo University Of Agriculture And Technology
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Tsujimura Noriyuki
Department Of Biotechnology Tokyo University Of Agriculture And Technology
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Nakasono Satoshi
Environmental Risk Assessment Sector Environmental Science Research Laboratory Central Research Institute Of Electric Power Industry:department Of Biotechnology Tokyo University Of Agriculture And Technology
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Otsuka Kensuke
Radiat. Safety Res. Cent., CRIEP
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