A New Paradigm in Radioadaptive Response Developing from Microbeam Research

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概要

• 論文の詳細を見る

• A classic paradigm in radiation biology asserts that all radiation effects on cells, tissues and organisms are due to the direct action of radiation on living tissue. Using this model, possible risks from exposure to low dose ionizing radiation (below 100 mSv) are estimated by extrapolating from data obtained after exposure to higher doses of radiation, using a linear non-threshold model (LNT model). However, the validity of using this dose-response model is controversial because evidence accumulated over the past decade has indicated that living organisms, including humans, respond differently to low dose/low dose-rate radiation than they do to high dose/high dose-rate radiation. These important responses to low dose/low dose-rate radiation are the radiation-induced adaptive response, the bystander response, low-dose hypersensitivity, and genomic instability. The mechanisms underlying these responses often involve biochemical and molecular signals generated in response to targeted and non-targeted events. In order to define and understand the bystander response to provide a basis for the understanding of non-targeted events and to elucidate the mechanisms involved, recent sophisticated research has been conducted with X-ray microbeams and charged heavy particle microbeams, and these studies have produced many new observations. Based on these observations, associations have been suggested to exist between the radioadaptive and bystander responses. The present review focuses on these two phenomena, and summarizes observations supporting their existence, and discusses the linkage between them in light of recent results obtained from experiments utilizing microbeams.

• Journal of Radiation Research 編集委員会の論文
• 2009-03-31

著者

• Hatashita Masanori

  Biology Group, The Wakasa Wan Energy Research Center

• Matsumoto Hideki

  Division Of Oncology Biomedical Imaging Research Center University Of Fukui

• Tomita Masanori

  Radiation Safety Research Center Central Research Institute Of Electric Power Industry

• Otsuka Kensuke

  Radiation Safety Res. Center Nuclear Technol. Res. Lab. Central Res. Inst. Of Electric Power Ind.

• Otsuka Kensuke

  Radiation Safety Research Center Nuclear Technology Research Laboratory Central Research Institute O

• Tomita Masanori

  Radiation Safety Research Center Nuclear Technology Research Laboratory Central Research Institute O

• Hatashita Masanori

  Biology Group Research And Development Department The Wakasa Wan Energy Research Center

• Matsumoto Hideki

  Division Of Forensic Pathology And Science Department Of Translational Medical Science Course Of Med

• Otsuka Kensuke

  Radiat. Safety Res. Cent., CRIEP

• Matsumoto Hideki

  Division of Oncology, Biomedical Imaging Research Center, University of Fukui

• Tomita Masanori

  Radiat. Safety Res. Cent., CRIEP

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