Intercellular and Intracellular Signaling Pathways Mediating Ionizing Radiation-Induced Bystander Effects

スポンサーリンク

概要

• 論文の詳細を見る

• A rapidly growing body of experimental evidence indicates that ionizing radiation induces biological effects in non-irradiated bystander cells that have received signals from adjacent or distant irradiated cells. This phenomenon, which has been termed the ionizing radiation-induced bystander effect, challenges the long-standing paradigm that radiation traversal through the nucleus of a cell is a prerequisite to elicit genetic damage or a biological response. Bystander effects have been observed in a number of experimental systems, and cells whose nucleus or cytoplasm is irradiated exert bystander responses. Bystander cells manifest a multitude of biological consequences, such as genetic and epigenetic changes, alterations in gene expression, activation of signal transduction pathways, and delayed effects in their progeny. Several mediating mechanisms have been proposed. These involve gap junction-mediated intercellular communication, secreted soluble factors, oxidative metabolism, plasma membrane-bound lipid rafts, and calcium fluxes. This paper reviews briefly the current knowledge of the bystander effect with a focus on proposed mechanisms. The potential benefit of bystander effects to cancer radiotherapy will also be discussed.

• 日本放射線影響学会の論文
• 2007-03-20

著者

• Matsumoto Hideki

  Dept. Exp. Radiol. Health Phys. Fukui Med. Univ.

• Matsumoto Hideki

  Division Of Oncology Biomedical Imaging Research Center University Of Fukui

• 木梨 友子

  京都大学原子炉実験所附属粒子線腫瘍学研究センター

• Kinashi Yuko

  Radiation Safety And Control Research Reactor Institute Kyoto University

• HAMADA Nobuyuki

  Department of Quantum Biology, Gunma University Graduate School of Medicine

• KOBAYASHI Yasuhiko

  Department of Quantum Biology, Gunma University Graduate School of Medicine

• Hamada Nobuyuki

  Department Of Quantum Biology Division Of Bioregulatory Medicine And The 21st Century Center Of Exce

• Kinashi Yuko

  Kyoto Univ. Research Rcactor Institute

• HARA Takamitsu

  Department of Quantum Biology, Gunma University Graduate School of Medicine

• Nagasawa H

  Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima

• Hattori Tomoyasu

  Dep. Of Biochemistry Gunma Univ. Graduate School Of Medicine

• Hiramitsu Tadahisa

  Department Of Quantum Biology Gunma University Graduate School Of Medicine

• Majima Hideyuki

  Departments Of Experimental Radiology And Health Physics

• Kobayashi Yasuhiko

  Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo

• Matsumoto Hideki

  Division Of Forensic Pathology And Science Department Of Translational Medical Science Course Of Med

• Matsumoto Hideki

  Department Of Biology Nara Medical University

関連論文

• Radiation Biology of Caenorhabditis elegans : Germ Cell Response, Aging and Behavior
• Impact of the p53 Status of the Tumor Cells on the Effect of Reactor Neutron Beam Irradiation, with Emphasis on the Response of Intratumor Quiescent Cells
• Effects of p53 Status on Radiosensitivity and the Size of Hypoxic Fraction of Intratumor Total and QuiescentCell Populations
• Evaluation of the Potential of p-Boronophenylalaninol as a Boron Carrier in Boron Neutron Capture Therapy, Referring to the Effect on Intratumor Quiescent Cells
• Sensitizing Effect of the Phosphatidylinositol 3-kinase Inhibitor Wortmannin on Thermal Neutron Irradiation with or without Boron Compound
• BNCT Effect of BPA-ol, a Derivative of BPA, and Enhancement by Hyperthermia
• The Effects of Boron Neutron Capture Therapy on Liver Tumors and Normal Hepatocytes in Mice
• The Combined Effect of Electroporation and Borocaptate in Boron Neutron Capture Therapy for Murine Solid Tumors
• Changes in the Sensitivity of Intratumor Cells during Fractionated Tirapazamine Administration
• Usefulness of Tirapazamine as a Combined Agent in Chemoradiation and Thermo-chemoradiation Therapy at Mild Temperatures: Reference to the Effect on Intratumor Quiescent Cells
• Effect of Electroporation on Cell Killing by Boron Neutron Capture Therapy Using Borocaptate Sodium (^B-BSH)
• Time-course Change in Oxygenation Status of Total and Quiescent Cell Populations in Solid Tumors after γ-ray Irradiation, Tirapazamine Injection or Cisplatin Treatment
• Applicability of Combination with Tirapazamine in Boron Neutron Capture Therapy
• 硼素中性子捕捉療法時の患部近傍での放射化の評価
• 癌放射線治療の新たなパラダイム : 硼素中性子捕捉療法(癌細胞選択的放射線治療)の現状と将来
• 放射線誘発バイスタンダー効果におけるDMSOの影響
• Recent Advances in the Biology of Heavy-Ion Cancer Therapy
• γ-ray Irradiation Enhanced Boron-10 Compound Accumulation in Murine Tumors
• A Simple and Rapid Method for Measurement of ^B-para-Boronophenylalanine in the Blood for Boron Neutron Capture Therapy Using Fluorescence Spectrophotometry
• Evaluation of Hypoxia-specific Cytotoxic Bioreductive Agent-sodium Borocaptate-^B Conjugates as ^B-carriers in Boron Neutron Capture Therapy
• S-4-4 From Regionally Selective Radiotherapy to Cellular Selective Radiotherapy(Aiming Further Development of Radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Usefulness of Hexamethylenetetramine as an Adjuvant to Radiation and Cisplatin in the Treatment of Solid Tumors : its Independency of p53 Status
• 硼素中性子捕捉療法(Boron Neutron Capture Therapy;BNCT)の現状と将来展望--癌細胞選択照射がもたらすWhole Organ Radiotherapyの可能性 (特集 放射線治療:画像誘導放射線治療--IGRTを中心に)
• 肝、肺腫瘍に対する硼素中性子捕捉療法の試み (第41回京都大学原子炉実験所学術講演会 報文集)
• 硼素中性子捕捉療法におけるDose Volume Histgram(DVH)解析 (京都大学原子炉実験所第39回学術講演会 報文集)
• 熱中性子照射におけるDNA-PKcs阻害剤の生物学的効果
• 癌のホウ素中性子捕捉療法--捕獲反応α粒子による細胞選択的放射線治療
• 肝腫瘍に対する硼素中性子捕捉療法の基礎的検討 (第37回京都大学原子炉実験所学術講演会)
• マイクロコンピューター支援による高精度コロニーアッセイ法を用いたSCCVII腫瘍に対する低酸素細胞増感剤の効果の検討
• 京大原子炉における悪性神経膠腫に対する硼素中性子捕捉療法
• Potentially Lethal Damage Repair by Total and Quiescent Tumor Cells Following Various DNA-damaging Treatments
• Enhancement of Cisplatin Sensitivity of Quiescent Cells in Solid Tumors by Combined Treatment with Tirapazamine and Low-Temperature Hyperthermia
• 9 Modulation of nitric oxide-mediated bystander effects by chronic irradiation with gamma-rays(Low dose and low dose-rate effects, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Modulation of NO-Mediated Bystander Effect by Pre-Gamma-Ray Irradiation with Low-Dose Rate
• Increase of wtp53 pool size in specific organs of mice by low doses of X-ray.
• Preferential Inhibition of Nucleosome Assembly by (6-4) Photo products,
• Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations
• Effective Suppression of Bystander Effects by DMSO Treatment of Irradiated CHO Cells
• Evaluation of Micronucleus Induction in Lymphocytes of Patients Following Boron-Neutron-Capture-Therapy : A Comparison with Thyroid Cancer Patients treated with radioiodine
• 84 Effects of Mild Temperature Hyperthermia and p53 Status of Tumor Cells on the Size of Hypoxic Cell Fractions in Solid Tumors(Radiation sensitivities in cells & tissues, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Effects of p53 Status and Wortmannin Treatment on Potentially Lethal Damage Repair, with Emphasis on the Response of Intratumor Quiescent Cells
• Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors : its independence of p53 status
• Development of Selective Irradiation Method to Blood Vessel
• Targeted Heavy-Ion Microbeam Irradiation of the Embryo But Not Yolk in the Diapause-Terminated Egg of the Silkworm, Bombyx mori, Induces The Somatic Mutation
• Homology between ABH-carrier α2-seminoglycoprotein and Mac-2 binding protein
• Induction of cdk2 by p53-dependent pathway after γ-ray irradiation
• Loss of p53 -dependent signal transdution in γ -ray irradiated scid mouse fibroblasts
• Contribution of PKC to accumulation of hsp72 after UV or heat treatment
• Induction of p53 and WAFJ in Heat-treated Human Glioblastoma cells
• Effect of p53-type on γ-ray or UV induced chromosomal aberration
• Measurement of the p53 cellular content in rats after the low dose X-rays irradiation
• 166 Modification of Radio- and Thermo-Sensitivity by Amrubicin or Amrubicinol in Human Lung Adenocarcinoma A549 Cells(Radio-protection and sensitization, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 159 p53-dependent regulation of induction of angiogenic regulatory factors by hyperthermia in vitro(Radio-protection and sensitization, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 158 p53-Independent Thermo-Chemo-Sensitization by NO Radical Generators in transplanted tumors(Radio-protection and sensitization, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Contribution of p53 Gene to Anti-Tumor Effects of Hyperthermia
• p53-Independent Thermo-Chemo-Sensitization by NO Radical Generators
• Modification of Thermosensitivity and Chemosensitivity Induced by Combined Treatments with Hyperthermiaand Adriamycin
• Bystander Effect Induced by Carbon-ion Beams : Modulation of Tumor Growth
• Cell growth and morphology of Dictyostelium discoideum in space environment
• Cell growth and morphology of Dictyostelium discoideum in space environment
• Comparison of Radiobiological Characteristics of Epirliermal Neutron Beams between KUR and JRR4
• Effects of Ionizing Radiation on Locomotory Behavior and Mechanosensation in Caenorhabditis elegans
• Vanguards of Paradigm Shift in Radiation Biology: Radiation-Induced Adaptive and Bystander Responses
• Radiation-Induced Adaptive Responses and Bystander Effects
• 165 Dose selenomethionine have radio-protective effect on cell lines with wild type p53?(Radio-protection and sensitization, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• DNA Damage Formation and p53 Accumulation in Mammalian Cells Exposed to the Space Environment
• The cellular content of p53 protein in rat skin after travelling to space
• p53 protein accumulated by γ-ray or UV irradiation associate with heat shock proteins HSP72/HSC73 in human glioblastoma cell lines
• Participation of Cyclobutane Type Pyrimidine dimers and (6-4) photoproducts to Killing and Mutation
• Mutagenic specificity in DNA base sequence by irradiation of α-particles in Escherichia coli.
• Effect of Locally Targeted Carbon-Ion Microbeam Irradiation on Learning Behavior in Caenorhabditis elegans
• Radiation-Quality Dependent Bystander Effects Induced in Normal Human Fibroblasts by X-ray, Proton and Heavy-Ion Microbeams
• Microbeam Irradiation Facilities for Radiobiology in Japan and China
• 熱中性子照射におけるDNA-PKcs阻害剤の生物学的効果
• ホウ素中性子捕捉療法後の末梢血リンパ球におけるマイクロヌクレウスの出現頻度の評価
• Distinct Response of Irradiated Normal Human Fibroblasts and Their Bystander Cells to Heavy-Ion Radiation in Confluent Cultures
• Ceramide Induces Myogenic Differentiation and Apoptosis in Drosophila Schneider Cells
• Heavy-ion-induced bystander killing of human lung cancer cells : Role of gap junctional intercellular communication
• 8^ International Workshop on Microbeam Probes of Cellular Radiation Response
• An Alternative Mechanism for Radioprotection by Dimethyl Sulfoxide; Possible Facilitation of DNA Double-strand Break Repair
• Effectiveness of Carbon-ion Beams for Apoptosis Induction in Rat Primary Immature Hippocampal Neurons
• Development of New Cell Targeting System for Heavy-ion Microbeam Systems at JAEA-Takasaki
• 分子シャペロン誘導剤は温度感受性変異p53の機能回復を促進する
• Contribution of Radiation-Induced, Nitric Oxide-mediated Bystander Effect to Radiation-Induced Adaptive Response
• Kinetic Analysis of Double-Strand Break Rejoining Reveals the DNA Reparability of γ-Irradiated Tobacco Cultured Cells
• Exposure of Normal Human Fibroblasts to Heavy-Ion Radiation Promotes Their Morphological Differentiation
• Contribution of Bystander Effect Initiated by Nitric Oxide to Interdisciplinary Cancer Therapy
• Accumulation of iNOS by Hyperthermia and Effect on the Coexisting Non-Treated Cells in Human Glioblastoma Cell Lines
• Accumulation of iNOS by Radiation and Effect on the Coexisting Non-Irradiated Cells in Human Glioblastoma Cell Lines
• Hyperthermic Enhancement of Cytotoxicity by Cisplatin or Radiation Depends on The p53 Status
• Hyperthermic Enhancement of Cytotoxicity by Cisplatin or Radiation Depends on The Accumulation of Hsp72
• Accumulation of iNOS by Radiation and/or Hyperthermia in Human Glioblastoma Cell Lines
• Possible mechanism on the cellular thermal damage induced by 40°C heating
• Intercellular and Intracellular Signaling Pathways Mediating Ionizing Radiation-Induced Bystander Effects
• A New Paradigm in Radioadaptive Response Developing from Microbeam Research
• Radiation-induced ICAM-1 Expression via TGF-β1 Pathway on Human Umbilical Vein Endothelial Cells ; Comparison between X-ray and Carbon-ion Beam Irradiation
• The influence of p53 function on the differences of cellular thermosensitivity between cell phases
• NO is a mediator of the intercellular signal transduction for stress response in human glioblastoma cells
• Indirect Influences of Radiation on Unirradiated Cells through Irradiated Cells
• がん温熱化学療法の増感メカニズムへの再訪--ラジカル産生が増感の鍵を握るのか?

もっと見る 閉じる

スポンサーリンク