Studies on lignan lactone antitumor agents. IV. Synthesis of glycosidic lignan variants related to .ALPHA.-peltatin.
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概要
- 論文の詳細を見る
Glycosidic variants of 1-β-hydroxy-α-peltatin and 1-β-hydroxy-8-<I>O</I>-methyl-α-peltatin were synthesized by glycosidation of 4′,8-di-<I>O</I>-benzyloxycarbonyl-1-β-hydroxy-α-peltatin or 4′-<I>O</I>-benzyloxycarbonyl-1-β-hydroxy-8-<I>O</I>-methyl-α-peltatin with the corresponding glucopyranose or 2-amino-2-deoxyglucopyranose derivatives. Among synthesized compounds, cyclic acetal of 1-<I>O</I>-β-(β-D-glucopyranosyl)-8-<I>O</I>-methyl-α-peltatin showed antitumor activity in mice with leukemia L-1210.
- 公益社団法人 日本化学会の論文
著者
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NISHIMURA Yoshio
Institute of Microbial chemistry
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KONDO Shinichi
Institute of Microbial chemistry
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Takeuchi Tomio
Institute For Chemotherapy M.c.r.f.
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Umezawa Hamao
Institute of Bioorganic Chemistry
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Saito Hitoshi
Institute of Microbial Chemistry
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Nishimura Yoshio
Institute of Bioorganic Chemistry
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