Studies on lignan lactone antitumor agents. V. 1-O-(aminoethyl) ther of 4'-O-demethyl-1-epipodophyllotoxin.

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概要

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• 1-<I>O</I>-(2-Aminoethyl)-4′-<I>O</I>-demethyl-1-epipodophyllotoxin derivatives were synthesized by a stereoselective BF<SUB>3</SUB>-catalyzed coupling of 4′-<I>O</I>-benzyloxycarbonyl-1-epipodophyllotoxin with the corresponding 2-aminoethanol derivatives, and with ethylene glycol followed by reductive amination of its aldehyde. Some 1-<I>O</I>-(2-aminoethyl) ethers of 4′-<I>O</I>-demethyl-1-epipodophyllotoxin prolonged markedly survival periods in mice with leukemia L-1210.

• 公益社団法人 日本化学会の論文

著者

• NISHIMURA Yoshio

  Institute of Microbial chemistry

• KONDO Shinichi

  Institute of Microbial chemistry

• Takeuchi Tomio

  Institute For Chemotherapy M.c.r.f.

• Saito Hitoshi

  Institute of Microbial Chemistry

• Komuro Keiko

  Institute of Microbial Chemistry

• Nishimura Yoshio

  Institute of Bioorganic Chemistry

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