Propranolol-Glucagon同時投与の成長ホルモン放出促進効果に関する研究

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In order to evaluate the effects of simultaneous administrations of propranolol and glucagon, the changes of plasma human growth hormone (HGH) and other hormones following the oral administration of 40 mg propranolol and the subcutaneous administration of 1 mg glucagon were observed in 9 normal subjects, 8 patients with pituitary dwarfism, 1 with Sheehan's syndrome, 3 with Turner's syndrome, 8 with anorexia nervosa, 1 with Fröhlich's syndrome, 2 with simple obesity, and 1 with hypogonadotropic eunuchoidism. The following results were obtained. (1) In normal subjects, Turner's syndrome, anorexia nervosa, hypogonadotropic eunuchoidism and simple obesity, the peak levels of plasma HGH in P-G administration were more than 8.3 ng/ml, while much lower peak levels were observed in other tests, insulin tolerance test, arginine tolerance test and L-Dopa test. On the other hand, in patients with pituitary dwarfism, Sheehan's syndrome or Fröhlich's syndrome, the peak levels of plasma HGH in P-G administration were less than 4.0 ng/ml. (2) In P-G administration, the significant increase of plasma cortisol level was observed in patients with isolated GH deficiency or anorexia nervosa as well as in normal subjects. (3) The plasma IRG levels increased significantly at 30 to 90 minutes and decreased at 180 minutes after P-G administration, and blood sugar levels increased at 30 to 60 minutes and decreased at 120 to 180 minutes. Plasma FFA revealed the lowest levels at 90 to 120 minutes. (4) Following the, subcutaneous administration of glucagon, plasma IRG increased significantly at 30 minutes, and maintained the high level even at 180 minutes. (5) There was no relationship between changes of plasma HGH level and other hormones. From these data P-G administration seems to be a more potent stimulation test for GH reserve, in comparison with other tests.
日本内分泌学会の論文

Propranolol-Glucagon同時投与の成長ホルモン放出促進効果に関する研究

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