横隔膜法によるplasma insulin activityについて特に糖代謝障害を伴う内分泌疾患に於ける知見
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The effects of several hormones-thyroxine, adrenalin, cortisol, adrenocorticotrophin and thyro-trophin-upon the glucose uptake by the isolated hemidiaphragm were investigated in vitro and the author found that the influences of these hormones in human plasma upon the glucose uptake diminish extremely or may be eliminated practically by the dilution of plasma. <BR>Using this method, the author estimated plasma insulin activities in normal subjects and some endocrine disorders. The following results obtained : <BR>1) The mean of fasting plasma insulin activities in 22 normal subjects was (3.16±0.45) × 10<SUP>-4</SUP>u. per ml. <BR>2) The fasting plasma insulin activities in diabetics were lower than in normal subjects and the activities in the insulin-requiring diabetics were lower than those in obese diabetics. In uncontrolled and insulin resistant diabetics, no insulin activity was found. <BR>3) In hyperthyroids, the activities were reduced, while in hypothyroids, they were within normal limits. <BR>4) In patients with Cushing's syndrome, hyperadrenocorticism, acromegaly, steroid diabetes and Fröhlich's syndrome, the activities were generally reduced. <BR>5) In patients with Addison's disease and anorexia nervosa the activities were somewhat elevated or within normal limits. <BR>6) When 0.1 unit of crystalline insulin per kg. body weight was injected intravenously into a normal fasting subject, the maximum of insulin activities was found in the plasma taken at 20 minutes after the injection. <BR>7) Plasma insulin activities in all cases of normal subjects increased markedly at 1 to 3 hours after the oral administration of 100g. of glucose. <BR>8) The author found that there were two types in diabetics. In the first type, plasma insulin activities increased, while the activities in the second type decreased after the administration of 100g. of glucose. Moreover, in some other endocrine disorders, the authors observed changes in blood sugars and insulin activities after the administration of 100g. of glucose, and the clinical significances of those changes were discussed.
- 日本内分泌学会の論文
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