D-フェニ-ルアラニンで出現する非経穴部刺激による鎮痛と針鎮痛との相違

概要

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The skin impedance of rat was measured at 86 different points on the body. Low impedance points were mostly found in lower extremities and were not found in the thigh and body trunk. Low frequency muscle stimulation of lower extremities, showing low impedance, caused analgesia which was measured by the tail-flick test ; while stimulation of thigh and abdominal muscles showed no analgesic effect. After treatment with 250 mg/kg D-phenylalanine, analgesia was produced by thigh muscle or abdominal muscle stimulation. Analgesia caused by stimulation of the lower extremity muscles was not antagonized by dexamethsone, while analgesia caused by thigh and abdominal muscle stimulation after D-phenylalanine was antagonized by dexamethasone. These data indicate that analgesia caused by stimulation of thigh muscle is caused by different endogenous morphine-like releasing mechanisms by stimulation of lower extremity muscles.
学校法人昭和大学・昭和医学会の論文