針麻酔の鎮痛発現の中枢径路

概要

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The effect of acupuncture (AA) and 0.5 mg/kg morphine analgesia (MA) measured by rat tail-flick latency were completely abolished by restricted lesion of the dorsal periaqueduct central gray (d-PAG), the anterior (AH), posterior (PH) or lateral hypothalamus (LH), the lateral septum (l-Sep), dorsal hippocampus (d-HPC), habenulo-interpeduncular tract (HP) or medial centromedian nucleus of thalamus (mCM) or hypophysectomy. Sham lesions made slighly above or lateral these lesions did not abolish AA or MA. Stimulation of these regions, except hypophysis, caused long lasting analgesia after cessation of stimulation and these analgesias were completely antagonized by naloxone. Evoked potentials caused by acupuncture stimulation were recorded from these regions. d-PAG stimulation-produced analgesia (SPA) was abolished by lesion of AH, 1-Sep, d-HPC, HP or mCM or by hypophysectomy. Lesion of the HP abolished 1-Sep-SPA, d-HPC-SPA or mCM-SPA. The AH-SPA disappeared after hypophysectomy. The mCM-SPA was abolished by lesion of d-HPC. It was estimated that 0.5 mg/kg morphine analgesia might be caused by morphine activation of the acupuncture afferent pathway from d-PAG to hypophysis. From these results and our previous reports, acupuncture afferent pathways were as follows.
学校法人昭和大学・昭和医学会の論文