針,モルヒネ鎮痛抑制系

概要

論文の詳細を見る
Acupuncture (AA), 0.5 mg/kg morphine (MA) and the dorsal periaqueduct central gray stimulation-produced (d-PAG-SPA) analgesia measured by rat tail-flick latency were augmented by lesion of the lateral centromedian nucleus of the thalamus (1-CM) .The augmentation of analgesia was prominent in acupuncture non-effective animals. Abolished AA and MA by lesion of the posterior, lateral hypothalamus, the lateral septum, cingulate bundle, dorsal hippocampus, habenulo-interpeduncular tract or the medial centromedian nucleus of thalamus reappeared as slightly larger analgesia than control after lesion of 1-CM, while abolished AA and MA by lesion of the d-PAG, anterior hypothalamus or hypophysectomy did not reappear after lesion of the 1-CM. Therefore, two acupuncture afferent pathways were recognized: one (R1) is inhibited by 1-CM and the other (R2) is not inhibited by 1-CM. The stimulation of 1-CM completely abolished AA, MA and d-PAG-SPA during stimulation in the R2-lesioned animals, while being partially inhibited in the presence of R1 and R2 pathways. Evoked potentials were not recorded from 1-CM by acupuncture stimulation and stimulation of 1-CM did not influence on tail-flick latency.
学校法人昭和大学・昭和医学会の論文