侵害刺激に応答する脳幹網様体単一ニュ-ロン活動に対する針刺激及び中脳中心灰白質刺激の作用
スポンサーリンク
概要
- 論文の詳細を見る
Neuronal unit activities responded to noxious stimulation were recorded extracellulary with metal microelectrodes from brainstem reticular formation in rats. The various types of responses in unit discharges to noxious stimulation were observed and classified to 1) the responses were limitted to stimulation periode (Type I), 2) the responses occured beyond stimulation periode (Type II), 3) combination of Type I and Type II. The responses to noxious stimulation were characterized by increase or decrease in firing rate.<BR>Therefore, the elemental types of responses were Type I excitatory (I <SUB>ex</SUB>), Type II inhibitory (I <SUB>in</SUB>) Type II excitatory (II <SUB>ex</SUB>) and Type II inhibitory (II <SUB>in</SUB>) . Combined responses of two types were I <SUB>ex</SUB>+II <SUB>ex</SUB>, I <SUB>ex</SUB>+II <SUB>in</SUB>, I <SUB>in</SUB>+II <SUB>ex</SUB> and I <SUB>in</SUB>+II <SUB>in</SUB><BR>Acupuncture stimulation inhibited the noxous responses in 40 of 81 noxious responded neurons. In I+II neurons, I or II response alone, or both I and II responses were inhibited by acupuncture stimulation.<BR>Electric stimulation of periaqueduct central gray (PAG) changed unit discharge rate in about half of noxious responded neurons. PAG-stimulation inhibited the noxious responded brainstem neurons in which firing rate were not changed by PAG stimulation. This inhibition last for long time beyond stimulation periode. Naloxone did not antagnize the inhibition during PAG stimulation, but antagnize the inhibition after termination of PAG stimulation.<BR>Above observations indicate that 1) I and II responses were caused by afferent impulses of different orgins which convergence in recorded neurons. and this difference was a basis of above classification of noxious responses. 2) acupuncture inhibtion might be presynaptic inhibition since one of two kinds of noxious responses was inhibited by acupuncture stimulation in some neurons.<BR>Inhibition of after termination of PAG stimulation was mediated by endogenous morphine like factor (MLF), while inhidition during PAG stimulation might be mediated by direct descending inhibitory system with other neurotransmitter than MLF.
著者
関連論文
- "ハリ麻酔"印象記(第19回日本医学会総会から)
- Vitamine B_およびAldosteroneの知覚・運動神経の興奮伝導に対する作用
- ビタミンB_の上皮電位及び神経の膜電位と活動電位に対する作用
- 中脳中心灰白質の部分的破壊によるモルヒネ鎮痛の減弱
- 中脳中心灰白質の部分的破壊による針鎮痛の消失
- 局所疼痛に対する針作用の実験的研究-4-強縮によって減少した収縮高の回復に対する傍脊椎施針の促進作用
- 侵害刺激に応答する脳幹網様体単一ニュ-ロン活動に対する針刺激及び中脳中心灰白質刺激の作用
- 周波数分析した動物催眠脳波の特性
- D-フェニ-ルアラニンで出現する非経穴部刺激による鎮痛と針鎮痛との相違
- モルヒネ耐性の形成で区分される針鎮痛発現系と鎮痛抑制系で抑制されている鎮痛発現系
- 針鎮痛抑制系破壊後経穴部,非経穴部刺激によって現われる鎮痛の性質
- 針,モルヒネ鎮痛抑制系
- D-フェニルアラニンによる針鎮痛,モルヒネ鎮痛,中脳中心灰白質刺激鎮痛の有効性の個体差の消失
- 針鎮痛の有効性の個体差と脳の内因性モルヒネ様物質の含有量個体差との相関関係
- 針麻酔の鎮痛発現の中枢径路
- 針麻酔の鎮痛に於ける内因性モルヒネ様物質とセロトニン系との関係