中脳中心灰白質の部分的破壊による針鎮痛の消失

概要

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Acupuncture stimulation (AS) increased the latency of rats' tail-flick test which estimated as pain threshold. In about 50% of examined animals (N=44), AS incresed pain threshold significantly (p<0.05) . In this connection, animals could be classified into acupuncture effective animals or non-effective animals by above criterion (p<0.05) . The acupuncture-produced analgesia (APA) were completely abolished by insertion electrode (diameter : 0.5mm) to periaqueductual cental gray (PAG) . Electrical stimulation of PAG caused analgesia, especially that of ventral PAG around aqueduct caused the profound analgesia. Pain threshold was not changed significantly (p <0.05) by electrode insertion to PAG. Electrical destruction of PAG also abolished the APA and pain threshold was not changed significantly (p<0.05) by destruction of PAG. After PAG stimulation, APA recovered slightly, however its changes were not significant. APA were partially abolished by administraion of naloxone (10mg/kg) . Abolishment of acupuncture analgesia by electrode insertion to PAG was disscused by 4 possible mechanisms.