近赤外線分光法によるFGR児の胎盤酸素動態の評価に関する研究

概要

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The purpose of this study is to evaluate fetal growth restriction (FGR) due to placental dysfunction by measuring oxygenation of the placenta using near-infrared spectroscopy. We selected 221 pregnant women with anterior placentation and a skin-to-placenta thickness of less than 3.5 cm; the subjects were divided into two groups, (1) normal fetal growth (195 patients, 222 cases) and (2) fetal growth restriction (26 patients, 45 cases) . Cases with fetal anomaly, multiple pregnancy and maternal complications were excluded. The measurement of tissue oxygenation index (TOT=oxyhemoglobin/total hemoglobin) was performed using the NIRO 300 model system (Hamamatsu Photonics KK), by attaching a probe to the maternal abdomen. We analyzed the relationship among TOT, placental weight, weeks of pregnancy and fetal weight. (1) TOT values were significantly higher in the FGR group than in the AGA group. TOT had a negative correlation regaiding fetal weight. (2) TOT showed a negative correlation for placenta weight, child birth weight/placental weight. Near-infrared spectroscopy could be used for measuring oxygenation status of the placenta and might help to evaluate placental function and severity of FGR due to placental dysfunction.
学校法人昭和大学・昭和医学会の論文