中枢性筋緊張弛緩剤Muscalmのめまいに対する治療効果:頭頚部外傷25症例における検討

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Twenty-five patients who had suffered from pain of both the neck and waist and had tended to develop vertigo and disequilibrium of the eyes and body due to over-excitment of the proprioceptors of these regions were treated with Muscalm, a centrally acting muscle relaxant.The results obtained were as follows: 1) This drug had a beneficial effect on some symptoms due to head and neck injury. It was more effective in treatment of vomiting, pain of the neck, stiffness of the neck and shoulder, vertigo, tremor of the four limbs, headache and pain of the waist. 2) There was a positive correlation between the improvement of vertigo and that of disequilibrium of the eyes and body. Furthermore, there was also a positive correlation between changes of the pain of the neck and waist and those of vertigo and disequilibrium of the eyes and body.From these findings, it can be postulated that when Muscalm normalizes the over-excitment of γ fibers involved in the proprioceptors in the neck and waist, hyperexcitability of the proprioceptors described above is first improved, and moreover, abnormal excitment of the equilibrium centers such as the hypothalamus, brain stem and cerebellum through the abnormal centripetal impulses from the proprioceptors is subsequently improved, As a result, the vertigo is relieved.
耳鼻咽喉科臨床学会の論文