耳鼻咽喉科領域における急性炎症性疾患に対する新消炎鎮痛剤SL-573の二重盲検法による臨床評価

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Clinical effects of SL-573 on acute inflammatory symptoms in Otorhinolaryngology were studied and compared with those of Indomethacin by a double-blind method.1. There were 28 patients given SL-573 and 26 given Indomethacin. By overall efficacy evaluation, in the SL-573 group there were 25 excellent, moderate and mild effective cases (89.3%) and 3 no changed cases, whereas in the Indomethacin group there were 22 excellent to mild effective cases (84.6%), 3 no changed cases and one worsened. By statistical analysis using X2-test and U-test, there was no significant difference between the two groups.2. There were also no significant differences between the SL-573 group and Indomethacin group in the subjective evaluation, the total effectiveness rate and the individual obj ective symptoms.3. Side effects were minimal (2 cases in each group) and were not severe. No change in laboratory tests was seen after the treatment.It was concluded that SL-573 is as effective and safe as Indomethacin in controlling acute inflammatory symptoms seen in patients in the Otorhinolaryngology clinic.
耳鼻咽喉科臨床学会の論文