オフロキサシンの基礎的ならびに臨床的検討--耳鼻咽喉科感染症における有効性

概要

論文の詳細を見る
1. Ofloxacin (OFLX) was administrated to 203 patients with ear, nose and throat infections.1) The overall efficacy rate (cases of excellent and good responses as judged by the attending otolaryngologist) was 83.0%.2) The overall efficacy rate, as judged by the committee, was 74.6%.3) The bacteriological sensitive rate for OFLX was 92.2%.4) The bacteriological efficacy rate was 81.0%.5) The rates of excellent and good results by X-ray findings were 72.7% for chronic paranasal sinusitis and 70.0% for acute exacerbation of chronic paranasal sinusitis6) Side effects were suspected in 3 patients (1.5%), but the symptoms were mild and no treatment was required.2. Tissue (sinus membrane) and serum levels were determined 5-6 hours after a dose of 200mg of OFLX. The concentrations were 1.10-3.40μg/ml in serum and 0.50-4.20μg/g in sinus membrane relatively high levels.These results indicated that OFLX is effective in the treatment of otolaryngeal infections.
耳鼻咽喉科臨床学会の論文