頭頚部のnon-Hodgkinリンパ腫--Stage1,2症例における化学療法の役割

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Forty-four cases of stage I and II non-Hodgkin's lymphoma were treated with radiotherapy with or without chemotherapy. All of the 44 patients had the lesion in Waldeyer's ring or paranasal sinuses. Antineoplastic agents used in chemotherapy were Bleomycin, 5-Fuorouracil, Chromomycin A3 or a combination regimen (cyclophosphamide-Vincristine-Predonison). Thirteen patients treated with radiotherapy alone received irradiation doses over 4, 000 rad, while 31 patients treated by the combined modality received more than 2, 400 rad.Relapsing lesions developed in 61.5 per cent of the patients after radiotherapy, while in 38.5 per cent treated with the combined therapy. The overall 5-year survival rate was 53.8 per cent for radiotherapy alone, while 74.2 per cent for the combined therapy, but this difference was not statistically significant. A low relapse rate and a high survival rate were seen in the group with the combined modality regardless of irradiation doses. The relapse-free 5-year survival rates for stage II cases were signifcantly different between the two treatment groups compared.We concluded that chemotherapy for stage I and II non-Hodgkin's lymphoma of the head and neck decreased the rate of relapse. The combined treatment for stage I and II non-Hodgkin's lymphoma is recommended.
耳鼻咽喉科臨床学会の論文