頭頸部悪性腫瘍に対する制癌剤の動脈内注入法に関する臨床的研究
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One hundred patients with malignant tumors of the head and neck have been treated by infusion chemotherapy for the past three years.Retrograde catheterization of the superficial temporal artery was performed in the most cases, by inserting a polyethylene tube of appropriated size until the tip of the tube was placed in the proximal part of the external carotid artery.The drugs were administered and daily doses of them were as follows : Toyomycin (chromomycin A3) 0.5mg/d., Mitomycin C 2.0mg/d., Endoxan (cyclophosphamide) 100mg/d., 5-fluorouracil 250 mg/d. Each drug was dissolved in 20m1. of 5% glucose or physiolgic saline. One of these drugs was infused through the catheter in a very short period of time (quick shot method) or infused for periods of one to two hours, by using an infusion pump.Eighty cases were treated by intra-arterial infusion of anticancer drugs, as an adjuvant method of radiotherapy or surgery. Twenty patients were treated by the combined method of infusion chemotherapy and the simultaneous irradiation. Out of 100 patients, thirteen were not evaluated for anticancer effects of the drugs because complications or side effects have occurred in these cases and infusion was discontinued within five days. Out of 87 patients, 22 had total or significant regression of the tumor and 38 had partial regression of the tumor and 27 had no response of the tumor. In the most cases the tumor regressed within 20 days after the bigining of infusion therapy. The Most cases, which were treated by the combined method of infusion chemotherapy and the simultaneous irradiation, had varying degrees of tumor regression.In the early stage of clinical trial, anticancer drugs for each patient, were selected at random, but since Nov, 1964, the drugs were selected, if possible, according to the results of SDI test, which is one of the sensitivity tests of anticancer drugs.In patients with malignant tumors of the maxillary sinus and the nasopharynx the good resunts were obtained. It is believed that the daily administration of an anticancer drug for periods of 20 days by quick shot method, followed by surgery or irradiation, is superior to the methods previously employed. The better results were obtained by the combined method of infusion chemotherapy (by quick shot method, for periods of 20 days) and the simultaneous irradiation with Cobalt or Linac. (4000_??_6000r of tumor doses).Leucopenia was noticed in 28 of 100 patients, in the most of them due to Mitomycin C and Endoxan. Mucositis of the oral cavity and alopecia of the infused side were found in 8 cases.
- 社団法人 日本耳鼻咽喉科学会の論文
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