頭頸部癌に対する多剤併用療法

概要

論文の詳細を見る
The application of some basic principles derived from studies of the cell cycle and prolifer-ative kinetics of normal and malignant cells has provided a rational basis for designing cancer treatment regimens. Since May 1979, 46 patients with malignant tumors of the head and neck region, of poor prognosis and generally in advanced stages, were treated with a combination of cytotoxic regimens. One regimen is M-phase synchronized combination chemotherapy, using Vincristine, Methotrexate, Bleomycin and Mitomycin-C and the other is S-phase synchronized combination chemotherapy, using Hydroxyurea, Adriamycin and Bleomycin.Positive response (more than 50% tumor regression) was obtained in 75% of the cases treated by M-phase synchronized combination and in 43% of the cases by S-phase synchronized combination.Lassitude and febrile response provided the main problems during treatment but they were transient. Late complications were bone marrow suppression but not very serious.These results would suggest a potential of combination chemotherapy for head and neck cancer of poor prognosis and in advanced stage.
社団法人日本耳鼻咽喉科学会の論文