Effect of Dilazep dihydrochloride in patients with vertigo.

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The usefulness of Dilazep dihydrochloride, an antiischemic multi activator, was investigated in the treatment of patients with vertigo of central or peripheral origin. A total of 83 patients in 9 hospitals were treated with Dilazep dihydrochloride singly (300mg/day) or in combination with a minor tranquilizer for 8 weeks.The clinical signs and symptoms were checked every 4 weeks. After 8 weeks of treatment, 64 patients (77.1%) were available for final evaluation.1. There was subjective improvement in 75.0%, and objective improvement in rate of 39.5%. The overall rate of improvement was 71.9%. The Final overall rate of effectiveness was as high as 70.3%.2. A layer analysis revealed that the rate of improvement was higher in older than in younger patients, and that improvement of vertigo of central and peripheral origin was almost equal. The rate of improvement of severely affected patients was higher than that of those with mild symptoms.3. There was no signicant difference between the group treated with Dilazep dihydrochloride and that treated with Dilazep dihydrochloride plus a minor tranquilizer.4. These results indicate that Dilazep dihydrochloride is effective in the treatment of vertigo. There were no side effects of this drug.
耳鼻咽喉科臨床学会の論文