Examination of the Olfactory Cleft in Congenital Anosmia.
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概要
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Nine patients with congenital anosmia were evaluated clinically and pathologically, and olfactory mucosal biopsy was performed in seven of them. Biopsied mucosa of the olfactory cleft was examined with H . E. and immunohistochemical staining.All patients were anosmic when tested with T&T olfactometry and intravenous Alinamine, but most of the patients were responsive to chemical irritants. Three of them had a family history of anosmia.Histopathologically, all specimens showed only respiratory mucosa. Immunohistochemical examination showed an absence of olfactory receptor cells which react with anti-neuron-specific enolase antiserum in all the mucosal specimens.These results indicate that olfactory mucosa is not present and the olfactory cleft is covered with respiratory mucosa in patients with congenital anosmia.
- 耳鼻咽喉科臨床学会の論文
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