Impairment of olfactory epithelium treated with Chlorhexidine digluconate (Hibitane) - Postoperative olfactory disturbances after Hardy's operation and results of experimental study.:Postoperative olfactory disturbances after Hardy's operation and results

概要

論文の詳細を見る
The transsphenoidal approach to pituitary adenoma (Hardy's operation) is a safe method which does not cause nasal dysfunction. Some patients, however, have suffered from olfactory disturbances after Hardy's operation. Three groups of patients were studied.Group 1 patients had hyposmia which soon improved after removal of the nasal tampon. The patients of group 2 had prolonged olfactory disturbance. Group 3 patients had hyposmia which improved three to seven weeks, it was assumed that the hyposmia of this group was caused by treatment with Chlorhexidine digluconate (Hibitane®) solution which was used for preoperative disinfection of the nasal cavity.To test the posibility of olfactory impairment by Hibitane, the nasal cavities of guinea pigs were irrigated three times with 5ml of 0.5% Hibitane solution. Saline solution was used as a control. Under Nembutal® anesthesia, olfactory epithelium from the superior-posterior part of the nasal septum was examined 3, 7-10, 14-17 and 30-35 days after Hibitane treatment. The samples were examined by light microscopy and scanning electron microscopy. Degeneration of the olfactory epithelium was evident over extensive areas three to seven days after treatment. Regeneration of the epithelium started at 14-17 days, and the surface appeared nearly normal at 30-35 days. These results suggest that olfactory epithelium is injured by Hibitane solution and recovers within about one month.Povidone iodine (Isodine®) solution (100mg/ml) was applied by the same method, but there was no change in olfactory epithelium.
耳鼻咽喉科臨床学会の論文

Impairment of olfactory epithelium treated with Chlorhexidine digluconate (Hibitane) - Postoperative olfactory disturbances after Hardy's operation and results of experimental study.:Postoperative olfactory disturbances after Hardy's operation and results

スポンサーリンク

概要

著者

関連論文

スポンサーリンク