めまい症例に対するCinnarizine(Roin)の治験

概要

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It has been reported that Cinnarizine is effective in suppressing postrotatory sensation and nystagmus in normal subjects and in patients with vestibular disorders (Philipszoon 1962) by producing direct vascular dilation in the brain and inner ear (Nagao 1972). The antivertiginous effects of Cinnarizine were evaluated in a controlled study in 24 patients with vertigo and/or dizziness, particularly with vestibular disorders.Clinical subjective signs and symptoms in these cases were evaluated every two weeks both by the physicians and the patients themselves. Objective symptoms were also evaluated using equilibrium and auditory examinations before treatment, two weeks thereafter and four weeks thereafter by the same doctors. Cinnarizine was given in dosages of 150mg daily for four weeks.Overall comparative judgment of the subjective and objective clinical findings revealed antivertiginous drug effects in 15 out of the 24 patients (62.5%) after four weeks ingestion.However, the effects on tinnitus and on fullness of ears were present in five of the 16 patients (31.3%), and in two of the ten patients (20%), respectively.Side-effects were minimal and only two patients were found to develop exanthema in the extremities after three weeks ingestion.
耳鼻咽喉科臨床学会の論文