Autolytic Degradation of Articular Cartilage
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概要
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In recent years considerable experimental evidence has led to the consideration of Cathepsin D as the chief agent in the degradation of cartilage matrix.However a report has appeared that neutral proteolytic activities are present in the cartilage and that these activities are involved in the degradation of proteoglycans. We tested the enzymatic properties of proteases with the use of autolysis of human articular cartilage.The pH optimum for the Alitolysis of articular cartilage are pH 5 and pH 7-8.The addition of pepstatin at pH 5 inhibited 50% of autolygic degradation of cartilage.On the other hand pepstatin had no inhibition at neutral pH.These experimental evidence has led to the conclusion that there are two or more distinct proteases in articular cartilage.
- 西日本整形・災害外科学会の論文
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