Two Cases of Metaphyseal Chondrodysplasia:An Ultrastructural Study of Growth Plate Cartilage

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The growth plate cartilages obtained from two patients with metaphyseal chondrodysplasia were investigated by light and electron microscopy.Histologically, the linear columns were irregular and occasionally round ball like clusters were seen in the hypertrophic zone.Electron microscopically, a large number of chondrocytes had dilated cisternae of rough-surfaced endoplasmic reticulum. Furthermore, the degenerating chondrocytes with enlarged mitochondria, dense nucleus, large lipid granules and numerous vacuoles were frequently observed even in the resting and proliferating zone. The cartilagenous matrix represented an unusual fibrillar appearance.The present study reveals that the involvement of the metaphysis in this disorder may be a result of degenerative changes due to the abnormal mechanism of protein biosynthesis or protein transport in resting and proliferating chondrocytes.
西日本整形・災害外科学会の論文