:Efficient methods for production of polyarthritis in SD rats
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When rats were injected intradermally with an oil emulsion of native type II collagen, approximately 40%, of them developed an imflammatory polharthritis.SD rats developed polyarthritis with high incidence, approximately 90%, after injection of1) high dose of bovine type II collagen or2) bovine type II collagen containing the synthetic adjuvant MDP (muramyl dipeptide).Whereas the usual dose of collagen alone produced polyarthritis with low incidence, approximately 50%, and MDP alone was non-arthritogenic.
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