The effect of tilorone on collagen arthritis in rats.

概要

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The effects of tilorone, which is known to suppress adjuvant arthritis, on collagen arthritis in rats were studied following oral administration of this drug at doses ranging from 6.25-25mg/kg/day for 15 days starting the day before type II collagen immunization. Combined date of the tilorone-treated rats show that there was an increased incidence of arthritis in the rats receiving tilorone treatment compared with the control group. In addition, treatment with tilorone caused a significant enhancement of the severity of collagen arthritis in a dose-dependeent manner. Although delayed-type hypersensitivity (DTH) skin test response to type II collagen was not affected by tilorone, humoral immune response to type II collagen was significantly enhanced in a dose-dependent manner. These data further support the concept that humoral immunity to type II collagen plays a predominant role in the development of collagen arthritis and also provide circumstantial evidence suggesting that collagen arthritis and adjuvant arthritis are distinctly different diseases mediated by different pathogenetic mechanisms.
西日本整形・災害外科学会の論文