Serum transfer of collagen arthritis in nude rats. A preliminary study.:a preliminary study
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We have studied the role of cellular immunity in collagen arthritis using athymic nude rats and their littermates. Immunization with type II collagen induced polyarthritis and definite immunity to type II collagen in normal rats, whereas nude rats did not develop arthritis nor immunity to collagen. An additional study demonstrated that collagen arthritis could be passively transferred with a serum concentrate from Sprague-Dawley rats to naive nude rats as well as their littermates. Despite no difference in clearance of anti-type II collagen antibody after transfer between nude rats and normal rats, the passively transferred arthritis in nude rats was significantly enhanced and prolonged as compared with that in normal rats. These results indicate that arthritis can be inducible by humoral immunity in the absence of functional T cells, and also suggest that anti-type II collagen antibody is not the sole regulatory factor and that suppressor cell system might play a role in regulation of the clinical course of the disease.
- 西日本整形・災害外科学会の論文
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