The effect of 1,25(OH)2D3 and calcitonin on the EHDP-induced rickets - Additive effect of 1,25(OH)2D3 and calcitonin.

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概要

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• We have already shown that 1, 25(OH)2D3 (D) and calcitonin ([Asu1.7]-eel calcitonin, CT) promotes calcification of the thickened growth plate in the healing stage of EHDP-induced rickets respectively. In the experiment female weanling Wistar King-A rats of 4 weeks of age were used and the experiment period was settled to be 2 weeks. Sixty mg/kg body weight of EHDP (ethane-1-hydroxy-1, 1-diphosphonate) was dosed subcutaneously, daily for the former 7 days and then they were left alone for the latter 7 days, that is the basic model, we have settled, of EHDP-induced rickets (EHDP rat). Forty U/kg body weight of CT was given to the EHDP rat for the 14 consecutive days (2), for the former 7 days (f), and the latter 7 days (1), that makes up 3 groups. 0.5μg/kg body weight of D was given in the same 3 ways. Our previous results showed that CT (2) and CT (f) groups promoted calcification in the growth plate, and D (2) and D (1) groups did so. Now in this study, both CT and D were admistered respectively either in the former 7 days or in the latter 7 days, making 4 groups. In the results, CT (f) D (f) group showed prominent calcification, whereas CT (f) D (1) group showed most massive calcification, and calcification was invisible except for the slightly narrowed plate in CT (1) D (f) group. These synergistic effects of CT and D, particularly shown in CT (f) D (1) group, are indicative of the difference of CT and D in the mode of calcification.

• 西日本整形・災害外科学会の論文

著者

• 江口 正雄

  九州大学整形外科

• 村尾 哲

  九州大学整形外科

• 川村 秀哉

  九州大学整形外科

• 島内 卓

  九州大学整形外科

• 柴田 直之

  九州大学整形外科

• 塩田 悦仁

  国立小倉病院整形外科

• 和田 文夫

  九州大学整形外科

• 柴田 堅二郎

  九州大学整形外科

• 池田 正一

  九州大学整形外科

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