The effects of long-term low-dose EHDP on experimental osteoporosis induced by ovariectomy and low calcium diet in rats.

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概要

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• The effects of long-term low-dose EHDP on experimental osteoporosis induced by ovariectomy and low calcium diet in rats have been investigated. EHDP was given at a dose of 0.5mg/kg daily for six months. Low calcium diet containing 0.1-0.2% Ca, 0.65-0.80% P and 2000 IU vitamin D3/kg was used.1) Osteoporosis induced by low calcium diet was more marked than that of ovariectomized rats.2) Both osteoporosis were clearly prevented by EHDP, judging from increased trabecular bone mineral content, cortical thickness, bone ash content and bending strength.3) These findings suggest that long-term low-dose EHDP can prevent the osteoporosis induced by ovariectomy and low calcium diet as well as the denervation osteoprosis.

• 西日本整形・災害外科学会の論文

著者

• 村尾 哲

  九大医学部整形外科

• 島内 卓

  九大医学部整形外科

• 塩田 悦仁

  国立小倉病院整形外科

• 松元 信輔

  九大医学部整形外科

• 川村 秀哉

  九大医学部整形外科

• 江口 正雄

  九大医学部整形外科

• 柴田 堅一郎

  九大医学部整形外科

• 和田 文夫

  九大医学部整形外科

• 豊福 不可依

  九大歯学部歯科放射線科

• 小西 圭介

  九大歯学部歯科放射線科

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