Effect of calcium antagonist on bone metabolism in experimental hypervitaminosis D.

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概要

• 論文の詳細を見る

• The present experiment was designed to study the effect of Ca antagonist Diltiazem (HERBESSER) on experimental hypervitaminosis D. Vitamin D3 was administered (600000U. I./kg) subcutaneously. Subcutaneously Calcium antagonist, diltiazem in dose of 100mg/kg, was injected every 12hr for 7 consecutive days after one single dose of Vit. D3. In bones of rats given Vit. D3 were observed sclerotic metaphysis and the formation of excessive osteoid tissue. Diltiazem neutralized the metaphyseal scleosis and reduced the excess osteoid tissue by overdose of vit D3. Ca antagonist revealed that intracellular Ca plays a key role in the action of Vitamin D3 on bone.

• 西日本整形・災害外科学会の論文

著者

• 村尾 哲

  九大医学部整形外科

• 島内 卓

  九大医学部整形外科

• 柴田 直之

  九大医学部整形外科

• 松元 信輔

  九大医学部整形外科

• 川村 秀哉

  九大医学部整形外科

• 江口 正雄

  九大医学部整形外科

• 柴田 堅一郎

  九大医学部整形外科

• 和田 文夫

  九大医学部整形外科

• 豊福 不可依

  九大歯学部歯科放射線科

• 小西 圭介

  九大歯学部歯科放射線科

• 塩田 悦仁

  九大医学部整形外科

• 池田 正一

  九大医学部整形外科

関連論文

• The effects of long-term low-dose EHDP on experimental osteoporosis induced by ovariectomy and low calcium diet in rats.
• The effect of calcium antagonist on bone and cartilage. The effect of Diltiazem on local calcergy.:The Effect of Diltiazem on Local Calcergy
• Effect of calcium antagonist on bone metabolism in experimental hypervitaminosis D.
• Effects of long-term low-dose EHDP on experimental osteoporosis induced by sciatic nerve dissection in rats. Part II: Studies on the mechanical property.:Part II: Studies on the Mechanical Property
• Inorganic Pyrophosphase Activities of Serum and Human Tissue Extracts
• The effects of (Asu1,7)-eel-Calcitonin on the morphology and the mechanical properties of the long bone diaphysis in EHDP induced rachitic rats.
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