Studies on Binding of the Tetracycline with Bone Salt

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It is well known that tetracycline (TC) and TC derivatives accumulate in the mineralizing tissues particularly in the newly formed bone tissue.This effect has been utilized as tetracycline labelling of the osseous tissue. However, those drugs cause the disagreeable yellow pigmentation of the bone and teeth in clinically administered doses for the young patients as antibiotics.In the present study, we examined the deposition in vivo of TC to bone, and the fixation in vitro with calcium phosphate and the human bone powder.The binding ability of each TC was compared.In comparison of the macroscopic staining, macroscopic fluorescence and histological labelling, less staining abilitty was confirmed in young rats given intraperitoneally deoxy-oxytetracycline than those receiving an equivalent dosage of oxytetracycline and demethylchlortetracycline.To check whether there might be the difference also in vitro, after shaking each TC with tribasic calcium phosphate and the bone powder, the residual TC in supernatant and the adsorbed TC in precipitate were measured by ultraviolet resorption at wave length of 370 to 380mμ and fluorometry at 510mμ.The results were consistent with the observation in vivo; the percentage of TC fixed to calcium phosphate and the bone powder were lower in deoxy-oxytetracycline than the others.It seems to show a primary importance of calcium salt in TC-bone complex that TC uptake of the bone powder decalcified by ethylendiaminetetraacetate decraesed remarkably.
西日本整形・災害外科学会の論文

Studies on Binding of the Tetracycline with Bone Salt

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