コイ肝膵臓中の2,3の酵素に及ぼすPCPおよびAPTの影響について

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The effects of sodium pentachlorophenolate (PCP-Na) and 2-amino-4-phenylthiazole (APT), known as a herbicide and an anesthetic of fishes, respectively, on the enzyme activities of lysosomal origin in the hepatopancreas of fishes were investigated using the carps (Cyprinus carpio LINNAEUS) as experimental sample. Although arylsulfatase activity in the extracts from the homogenates was hardly detected in any sample, the activities of β-glucuronidase, acid phosphatase and acid ribonuclease were readily detected. The three enzyme activities changed in almost similar patterns after the injection of a saline solution containing PCP-Na. The enhancement of enzyme activities after 24hr from the injection was highest on 5μg in jection/g body weight and those on 10μg and 15μg in jectlons/g body weight were followed in this order. Time course of the effect by the 15μg PCP-Na injection attained a maximum after 12hr from the injection, and then rapidly decreased. The enzyme activities, particularly, β-glucuronidase activity, were enhanced to some extents by the injection of saline solution only. Changes in the activities of the three enzymes during culture in a medium containing 0.1ppm PCP-Na and those in a medium containing 10ppm APT were compared, and it was found that the changes by both substances were, though a similar pattern being observed among the changes by individual drugs, significantly different in the patterns, suggesting that mechanism of the effects of these substances on lysosomal enzyme activities may be different from each other.
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コイ肝膵臓中の2,3の酵素に及ぼすPCPおよびAPTの影響について

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