Streptococcus sp.および各種魚病細菌に対するジョサマイシンの試験管内抗菌作用

概要

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The in vitro antibacterial activity of josamycin (JM) was investigated in comparison with erythromycin (EM) and spiramycin (SPM). Minimum inhibitory concentrations (MIC) of JM against Streptococcus sp. isolated in 1984 and 1986 from diseased fish in Ehime ranged from 0.10 to 0.39μg/ml. These values were higher than SPM but lower than EM. The antibacterial specfrom of JM was evaluated using various fish pathogenic bacteria: Streptococcus iniae, Staphylococcus epidermidis, Flexibacter maritimus, Pasteurella piscicida, Aeromonas salmonicida, Aeromonas hydrophila, Vibrio anguillarum, and Edwardsiella tarda. JM showed strong antibacterial activities to Gram-positive bacteria, but weak to Gram-negative bacteria. Development of resistance of Streptococcus sp. to the above macrolides was evaluated by broth subcultivation procedures and by cross resistance. The results showed a 4-fold increase in MIC value for JM and 8-fold for EM and SPM after 9 successive subcultivations. Acquired JM resistance was cross resistant to SPM, but not to EM.
日本水産學會の論文