1984年および1985年に養殖ブリから分離されたPasteurella piscicidaの薬剤感受性

概要

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Various chemotherapeutics have been used for the treatment of diseased cultured yellowtail caused by Pasteurella piscicida. Recently however, an increased number of strains have shown resistance to some chemotherapeutics. This study determines the drug sensitivity of 307 strains of P. piscicida isolated from diseased cultured yellowtail collected from 1984 to 1985 in different prefectures in Japan. The sensitivity of the P. piscicida strains to various chemotherapeutics was determined by conducting minimum inhibitory concentrations (MIC) usiag the agar dilution procedure of the Japanese Society of Chemotherapy. The MIC of the strains were determined after 48h incubation at 25°C. The strains showed high sensitivity to ampicillin (ABPC) and oxolinic acid (OA) and were moderately sensitive to nalidixic acid (NA) and sodium nifurstyrenate (NFS-Na). Most of the strains were highly resistant to chloramphenicol (CP), thiampheniocol (TP), tetracycline (TC), chlortetracycline (CTC) and oxytetracycline (OTC) but showed low resistance to doxycycline (DOTC). In 1984, 49% of the strains showed resistance to ABPC, and 13% to OA and NA. On the other hand in 1985, 34% of the strains showed resistance to ABPC and 25% to OA and NA. The strains resistant to both ABPC and OA overlap each other insignificantly.
日本水産學會の論文