エリスロマイシンに関する魚病化学療法的研究-2-養殖ハマチの連鎖球菌症に対する野外治療効果

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Efficacy of erythromycin (EM) against spontaneous streptococcal infection in cultured yellowtails Seriola quinqueradiata was evaluated clinically. The present studies given seven experiments were accomplished from August to October in 1978. The fish tested were 1st (80, 500 fish) and 2nd (29, 100 fish) year fish of cultured yellowtails being raised at fish farms in Kochi and Kagoshima prefectures.<BR>All of the clinical isolates of Streptococcus sp. from naturally infected fish were susceptible to EM, tetracycline, ampicillin and chloramphenicol, but resistant to sulfamonomethoxine. The minimal inhibitory concentration of EM was ranged from 0.1 to 0.2μg/ml and was the lowest in the tested drugs.<BR>In the clinical studies, EM was mixed in minced mackerel or mackerel pikes with formula feed and a binder, and consecutively administered for 4-7 days at the dose of 25-50mg/kg/day. The diseased fish, in every experiment, responded to EM with reduction in mortality and were found to be controlled of the disease during medication or within a few days post dosing. The efficacy of EM against streptococcal infection was more remarkable than those of oxytetracycline (50-80mg/kg/day) and ampicillin (20mg/kg/day). EM was also effective against the disease which couldn't cured by ampicillin.<BR>The administration of EM caused no clinical abnormality in about 100, 000 fish of cultured yellowtails. The results of the present study suggest that EM can be used for the control of streptococcal infection in cultured yellowtails.
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エリスロマイシンに関する魚病化学療法的研究-2-養殖ハマチの連鎖球菌症に対する野外治療効果

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