STUDIES ON THE UNCLASSIFIED MYCOBACTERIA:III. An Interesting Strain on the Unclassified Mycobacteria (Terai Strain)

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(1) Experiments in guinea pigs Guinea pigs were inoculated with 1mg and 10mg of the Terai strain subcutaneously andwere sacrificed after 2, 4, 6 and 8 weeks, one animal at each time. Comparison was madewith guinea pigs inoculated with 0.01mg of virulent human tubercle bacilli, Kurono strain. Skin reaction to 100 fold dilution of old tuberculin were positive after 4 to 6 weeks in bothgroups and it was more marked in the group inoculated with than that inoculated with 0.1mg, although still weaker than in the group inoculated 10mg with Kurono strain. The weight ofspleen was heavier in the Terai strain group than in the Kurono strain group, being morethan twice heavier 8 weeks after the inoculation. There were complications of pleurisy andperitonitis in many of the Terai strain group but no such compliations in the Kurono straingroup. The macroscopic pathological findings in lymph nodes and other organs were muchmore marked in the Kurono strain group. But microscopically the tubercles were seen in allthe organs examined, i.e. spleen, liver and lung, regardless of the amount of inoculation, andthe time of sacrifice. The number of tubercles was generally the most in spleen, then in liverand the least in lung. Colony counts per 1mg of the organs, were less in the group inoculatedwith 1mg than that with 10mg and were more in spleen and liver than in lung. With thelapse of time, colonies became less in mumber but were still present 8 weeks after the inoculation. This tendency was the same in the Kurono strain group. The Terai strain is considered to possess considerable virulence to the guinea pig. (2) Experiments in rabbits and hens. Both rabbits and hens were inoculated with 10mg of the bacteria subcutaneously and weresacrificed 8 and 12 weeks after the inoculation. The rabbits revealed tubercles only in the regional lymph nodes and no lesion in otherorgans macroscopically. Histological examination proved these results, i.e. only tubercles inthe regional lymph nodes and no tupercles in other organs. Cultures yielded colonies from theinoculated site, the regional lymph nodes, and mesenteric lymph nodes but only a few colonies from the liver at 8 weeks after the inoculation. Other organs faild to yiels the bacteria.These results are coincident with the pathological findings. In hens, there were no macroscopical lesions seen but microscopically many tubercles wereseen at the inoculated site and a few in the liver. Cultures yielded many colonies from theinoculated site and a few from the spleen, liver and lung. Consequently the Terai strain seems to have no or only a slight, virulence to rabbits andhens. Summary of the first, second and the third reports. The Terai strain which was isolated from a patient appears to be a strain of non-photochromogen type of the nuclassified mycobacteria from the clinical data and the various in-vitroexperiments. The pathogenicity of the strain to animals was investigated. The results show that the strain possess approximately the same degree of virulence to themouse as virulent human tubercle bacilli, Kurono strain, with intravenous inoculation. Thevirulence was less to the guinea pig than that of the Kurono strain with subcutaneous inoculation.It seems to have no or slight virulence to the rabbit and the hen, with subcutaneous inoculation.
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STUDIES ON THE UNCLASSIFIED MYCOBACTERIA:III. An Interesting Strain on the Unclassified Mycobacteria (Terai Strain)

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