STUDIES ON THE UNCLASSIFIED MYCOBACTERIA:I. An Interesting Strain of the Unclassified Mycobacteria (Terai Strain)

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From a male patient, 37 years old, with pulmonary lesions belonging either to rI2 type according to the classification of the Japanese Tuberculosis Association or to the moderately advanced type according to the classification of American Tuberculosis Association, a strain of unclassified mycobacteria, probably of nonphotochromogen type, was isolated by the present authors. This strain was named Terai strain, and regarding to its characteristics and the clinical pictures of the case likely to have been caused by this strain, there were observed several different points from those formerly reported which will be discussed in the present paper. Clinically the patient had intestinal symptoms associated with diarrhea and tuberculous bronchitis, Type III, on bronchoscopy. By the treatment with various anti-tuberculous drugs, diarrhea and bronchitis gradually improved but chest X-ray findings did not change, for which surgical resection was performed. The lesions in the lung appeared quite similar to tuberculous lesion treated with anti-tuberculous drugs macro-and microscopically. The patient was cured by surgery and now is under further observation. From bacteriological viewpoints, the sputa were purulent, always positive of acid-fast bacilli in five smear tests and yielded many colonies in culture tests. Numerous colonies were observed also in the culture test with stool specimens, the number of which decreased gradually with the decrease of diarrhea due to the treatment, becoming finally negative. In addition, the resected lung was positive on smear test and yielded many colonies. The same strain was recovered from sputa, stool and resected lungs, but no tubercle bacilli were detected. The bacteria were of short rods both on direct smear from the lesion and on smear from the cultured media, yielded gray-white, smooth colonies and became grossly visible within 4 days at 37°C or at room temperature when successively inoculated on media. Niacin test was negative. The strain was naturally resistant to SM, PAS, PZA and VM but sensitive to 1314 Th and cycloserine. To INH the strain gained resistance during the treatment. When inoculated to animals and recovered from them, the resultant colonies, if found as isolated colonies, dissociated to R type and S type. The R typed revealed yellow color after being exposed to room temperature, just as in the photochromogen. Urease test was positive. The S type, however, did not show any coloring and was negative of urease test.
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STUDIES ON THE UNCLASSIFIED MYCOBACTERIA:I. An Interesting Strain of the Unclassified Mycobacteria (Terai Strain)

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