Comparison of SM, PAS and Sensitivity Test Results Obtained with 1 % and 3 % Ogawa Media.

概要

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According to the Guide for Japanese Standard Tests concerning the SM, PAS and INH sensitivity tests, 3 % Ogawa medium is to be used for the direct method, and 1 % or 3 % Ogawa medium for the indirect method. When one observes the changes in the results of a series of sensitivity tests performed on a single patient by using various types of media, he will find that the results are not arranged in expected order. One of the reasons known to us for a long time is that there is a difference in sensitivity test results obtained with various media. However, there has been no report of clear cut results on this subject. Thus, following the Guide for Japanese Standard Tests, 0.1 ml. of 4 %NaOH treated sputa or suspension of tubercle bacilli was inoculated on the 3 % Ogawa media containing 10r and 100γ of SM, 1γ and 10γ of PAS, 0.1γ, 1γand 5 γ/ml of INH, and 0.1ml. of neutralized sputa and suspension of bacilli on the 1 % Ogawa media. Then, the results of the sensitivity tests obtained from the bacilli grown on these two media were compared. Samples used were sputa, and tubercle bacilli isolated from sputa gastric content, laryngeal swabs of the patients suffering from pulmonary tuberculosis having received or receiving SM, PAS and INH, and the tuberculous lesions of surgically resected lungs, totalling 284. The following is the result obtained.
一般社団法人日本結核病学会の論文