M. intracellulare感染症の実験的研究 (2) マウス系統間にみられる感受性差

概要

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A comparison was made on the susceptibility of 9 strains of mice against infection with 2 virulent strains of M. intracellulare. C57BL/6, BALB/c and CF1 mice were found to be susceptible; number of colony-formers increased in the livers and the spleens of these mice when inoculated with 107 viable bacilli intravenously. Histopathologically a large number of granulomas appeared in the livers and the spleens of mice when tested on the 21st day after infection. Other 6 strains of mice (A/J, ASW, CBA, C3H/He, DBA/2 and ddY) were resistant; number of colony-formers did not increase in the livers and the spleens, and only small numbers of granulomas could be detected at the 21st day after infection. From these results, it was thought that the different susceptibilities in different mouse strains were controlled genetically by non-H-2 linked gene (s), because mice with the same H-2 haplotype, BALB/c and DBA/2, showed different susceptibility to M. intracellulare. C57BL/6 mice were susceptible against low virulent M. intracellulare; number of colony-formers in the spleens and the lungs decreased once 3 weeks after infection, and then continued to increasetill 45 weeks of observation period. Severe granulomatous lesions appeared in the livers, the spleens and the lungs at the later stage of infection.
日本結核病学会の論文