レンサ球菌感染とその続発症の研究-1-レンサ球菌のマウス生体内における局在性と持続性について

概要

論文の詳細を見る
Group A streptococci (type 5) were labeled with relatively low concentrations (50-100mcg/ml) of fluorescein isothiocyanate (FITC). At these concentrations neither the viability nor the ability of the cells to produce acid from glucose was influenced. Not a change was observed in the staining intensity of the cells after treatment with HCl, pronase, trypsin, and 5% trichloroacetic acid. It was suggested that the mucopeptide fraction of the cells might have been labeled.FITC-labeled cells were injected into mice intravascularly or intraperitoneally. It was observed that these cells or their fragments were persistent in the reticuloendothelial system or kidney and heart of the mice for 45 days. No pathological changes, however, were found in the kidney or heart tissue.
日本細菌学会の論文