Effect of emeriamine, an inhibitor of fatty acid oxidation, on metabolic fate of a geometrical isomer of linoleic acid in perfused rat liver
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概要
- 論文の詳細を見る
To estimate the relative significance of exogenous vs. endogenous fatty acids in increasing hepatic triacylglycerol secretion following an inhibition of fatty acid oxidation by emeriamine, livers from 2-d-fasting rats were perfused with or without an inhibitor in the presence of a geometrical isomer of linoleate (linolelaidic acid, trans,trans-9,12-octadecadienoic acid). Emeriamine added to the perfusion medium at 2 h of the recirculating perfusion period caused immediate and complete cessation of ketone body production while it increased triacylglycerol and cholesterol secretion by the liver without affecting uptake of exogenous linolelaidic acid. The increase in the triacylglycerol secretion by emeriamine was accompanied by a marked increase in the proportion of linolelaidic acid in this lipid molecule in the perfusate and in the liver. The calculated amounts of exogenous linolelaidate, compared with those of endogenous fatty acids in the secretory triacylglycerol, suggested that the former compared with the latter contributes more to the drug-mediated increase in triacylglycerol secretion. This drug caused a marked reduction of mitochondrial carnitine palmitoyltransferase activity in perfused liver. These results suggest that a blockade of fatty acid oxidation by emeriamine, through an inhibition of carnitine palmitoyltransferase, diverts predominantly the exogenous free fatty acids from oxidation to the esterification pathway and subsequently stimulates the synthesis and secretion of triacylglycerol-rich lipoproteins.
- The Vitamin Society of Japan,日本ビタミン学会,University of Tokyo Pressの論文
著者
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Yamamoto Kyosuke
Department Of Applied Biological Sciences Saga University
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Sakono Masanobu
Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture University Of Miyazaki
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Fukuda Nobuhiro
Dep. Of Biochemistry And Applied Biosciences Fac. Of Agriculture Univ. Of Miyazaki
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Fukuda Nobuhiro
Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture Miyazaki University
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Ide Takashi
Laboratory Of Nutrition Biochemistry Division Of Physiology And Nutrition National Food Research Ins
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Fukui Masanori
Department Of Computer Science And Electronics Kyushu Institute Of Technology
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MAEDA Hideo
Faculty of Health and Living Sciences, Naruto University of Education
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JAYASOORIYA Anura
Department of Biological Resource Sciences, Faculty of Agriculture
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KAI Yasuko
Department of Biological Resource Sciences, Faculty of Agriculture, Miyazaki University
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FUKUI Masanori
Department of Biological Resource Sciences, Faculty of Agriculture, Miyazaki University
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JAYASOORIYA Anura
Department of Biological Resource Sciences, Faculty of Agriculture, Miyazaki University
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IDE Takashi
Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Fisheries and Forestry
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IDE Takashi
Laboratory of Nutrition Biochemistry
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MAEDA Hideo
Faculty of Health and Living Sciences, Graduate School of Education, Naruto University of Education
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