口腔外科領域におけるアスポキシシリン (ASPC, TA-058) の基礎的検討

概要

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Experimental study on Aspoxicillin (ASPC, TA-058), a new parenteral penicillin was carried out and the folloing results were obtained: In vitro antibiotic activity of ASPC against 47 clinical isolates from oral infection cases were examined. The peak of the minimum inhibitory concentration was 0.39 μ g/ml and 80% inhibitory concentration was 1. 56 μ g/ml. Using SD strain rats, distribution of ASPC, ABPC and PIPC after intravenous administration in plasma and in oral tissues such as the gingiva, mandible, alveolus, submaxillary gland, tongue and masseta were assayed. Concentration after administration of ASPC in plasma and oral tissues was similar to that ABPC and superior to that of PIPC. These results suggested usefulness of Aspoxillin in the treatment of infections in the field of oral surgery.